Evidence for Pathogen-Driven Selection Acting on HLA-DPB1 in Response to Plasmodium falciparum Malaria in West Africa

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985912%3A_____%2F25%3A00617884" target="_blank" >RIV/67985912:_____/25:00617884 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/ece3.70933" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ece3.70933</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ece3.70933" target="_blank" >10.1002/ece3.70933</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evidence for Pathogen-Driven Selection Acting on HLA-DPB1 in Response to Plasmodium falciparum Malaria in West Africa

Popis výsledku v původním jazyce

We investigated the molecular variation of four Human Leukocyte Antigens (HLA) class II genes (DRB1, DQA1, DQB1 and DPB1), directly involved in the immune response to parasitic infections, in more than 1000 individuals from 23 populations across North, East, Central and West Africa. We identified divergent genetic profiles for several (semi-) nomadic populations of the Sahel belt as a signature of their unique demography and observed significant genetic structuring supporting both substantial geographic and linguistic differentiations within West Africa. The most striking observation comes from linear modeling, demonstrating that the prevalence of Plasmodium falciparum, the primary pathogen of malaria in Africa, significantly explains a large proportion of the nucleotide diversity observed at the DPB1 gene. DPB1*01:01, a highly frequent allele in populations from Burkina Faso, is identified as a potential protective allele against malaria, suggesting that strong pathogen-driven positive selection at this gene has shaped HLA variation in Africa.

Název v anglickém jazyce

Evidence for Pathogen-Driven Selection Acting on HLA-DPB1 in Response to Plasmodium falciparum Malaria in West Africa

Popis výsledku anglicky

We investigated the molecular variation of four Human Leukocyte Antigens (HLA) class II genes (DRB1, DQA1, DQB1 and DPB1), directly involved in the immune response to parasitic infections, in more than 1000 individuals from 23 populations across North, East, Central and West Africa. We identified divergent genetic profiles for several (semi-) nomadic populations of the Sahel belt as a signature of their unique demography and observed significant genetic structuring supporting both substantial geographic and linguistic differentiations within West Africa. The most striking observation comes from linear modeling, demonstrating that the prevalence of Plasmodium falciparum, the primary pathogen of malaria in Africa, significantly explains a large proportion of the nucleotide diversity observed at the DPB1 gene. DPB1*01:01, a highly frequent allele in populations from Burkina Faso, is identified as a potential protective allele against malaria, suggesting that strong pathogen-driven positive selection at this gene has shaped HLA variation in Africa.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

60102 - Archaeology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ecology and Evolution

ISSN

2045-7758

e-ISSN

2045-7758

Svazek periodika

15

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

18

Strana od-do

e70933

Kód UT WoS článku

001429401400001

EID výsledku v databázi Scopus

2-s2.0-85219091470