Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985939%3A_____%2F10%3A00349719" target="_blank" >RIV/67985939:_____/10:00349719 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/10:00049612

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?

Popis výsledku v původním jazyce

Gap-junctional intercellular communication (GJIC) and mitogen-activated protein kinases (MAPKs), well-established biomarkers of tumor promotion, were affected by cyanobacterial extracts in in vitro experiments with rat liver epithelial cells. Since the observed effects of cyanobacterial extracts did not correlate with the content of known hepatotoxic cyanotoxins, and the pure toxins (microcystin, cylindrospermopsin, lipopolysaccharides) affected neither GJIC nor MAPKs, the effects were most likely induced by not-yet characterized chemicals of produced by cyanobacteria. These mechanisms (inhibition of GJIC, activation of MAPKs) and chemicals may thus contribute to the tumor promoting activity of toxic cyanobacteria.

Název v anglickém jazyce

Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts-Indications of novel tumor-promoting cyanotoxins?

Popis výsledku anglicky

Gap-junctional intercellular communication (GJIC) and mitogen-activated protein kinases (MAPKs), well-established biomarkers of tumor promotion, were affected by cyanobacterial extracts in in vitro experiments with rat liver epithelial cells. Since the observed effects of cyanobacterial extracts did not correlate with the content of known hepatotoxic cyanotoxins, and the pure toxins (microcystin, cylindrospermopsin, lipopolysaccharides) affected neither GJIC nor MAPKs, the effects were most likely induced by not-yet characterized chemicals of produced by cyanobacteria. These mechanisms (inhibition of GJIC, activation of MAPKs) and chemicals may thus contribute to the tumor promoting activity of toxic cyanobacteria.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EF - Botanika

OECD FORD obor

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Projekt

<a href="/cs/project/GA524%2F08%2F0496" target="_blank" >GA524/08/0496: Mechanismy nádorové promoce metabolitů toxických sinic</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicon

ISSN

0041-0101

e-ISSN

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Svazek periodika

55

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000273921500016

EID výsledku v databázi Scopus

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