Understanding immunity. An alternative framework beyond defense and strength

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985955%3A_____%2F23%3A00571591" target="_blank" >RIV/67985955:_____/23:00571591 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/s10539-023-09893-2" target="_blank" >https://doi.org/10.1007/s10539-023-09893-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10539-023-09893-2" target="_blank" >10.1007/s10539-023-09893-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Understanding immunity. An alternative framework beyond defense and strength

Popis výsledku v původním jazyce

In this paper we address the issue of how to think about immunity. Many immunological writings suggest a straightforward option: the view that the immune system is primarily a system of defense, which naturally invites the talk of strong immunity and strong immune response. Despite their undisputable positive role in immunology, such metaphors can also pose a risk of establishing a narrow perspective, omitting from consideration phenomena that do not neatly fit those powerful metaphors. Building on this analysis, we argue two things. First, we argue that the immune system is involved not only in defense. Second, by disentangling various possible meanings of “strength” and “weakness” in immunology, we also argue that such a construal of immunity generally contributes to the distortion of the overall picture of what the immune system is, what it does, and why it sometimes fails. Instead, we propose to understand the nature of the immune system in terms of contextuality, regulation, and trade-offs. We suggest that our approach provides lessons for a general understanding of the organizing principles of the immune system in health and disease. For all this to work, we discuss a wide range of immunological phenomena.

Název v anglickém jazyce

Understanding immunity. An alternative framework beyond defense and strength

Popis výsledku anglicky

In this paper we address the issue of how to think about immunity. Many immunological writings suggest a straightforward option: the view that the immune system is primarily a system of defense, which naturally invites the talk of strong immunity and strong immune response. Despite their undisputable positive role in immunology, such metaphors can also pose a risk of establishing a narrow perspective, omitting from consideration phenomena that do not neatly fit those powerful metaphors. Building on this analysis, we argue two things. First, we argue that the immune system is involved not only in defense. Second, by disentangling various possible meanings of “strength” and “weakness” in immunology, we also argue that such a construal of immunity generally contributes to the distortion of the overall picture of what the immune system is, what it does, and why it sometimes fails. Instead, we propose to understand the nature of the immune system in terms of contextuality, regulation, and trade-offs. We suggest that our approach provides lessons for a general understanding of the organizing principles of the immune system in health and disease. For all this to work, we discuss a wide range of immunological phenomena.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

60301 - Philosophy, History and Philosophy of science and technology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biology & Philosophy

ISSN

0169-3867

e-ISSN

1572-8404

Svazek periodika

38

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

25

Strana od-do

7

Kód UT WoS článku

000937160000001

EID výsledku v databázi Scopus

2-s2.0-85148415433