Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F01%3A17013050" target="_blank" >RIV/68081707:_____/01:17013050 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes.

Popis výsledku v původním jazyce

Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethal gamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time window (72h before and 48h after irradiation). L-AdDP significantly increased non-specific immunity against Candida albicans infectious model. L-AdDP could be therapeutically beneficial to moderate the haemopoietic damage and induce non-specific immunity to support the antimicrobial treatment of immunocompromised patients.Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethalgamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time wi

Název v anglickém jazyce

Stimulation of nonspecific immunity, haemopoiesis and protection of mice against radiation injury by 1-adamantylamide-L-alanyl-D-isoglutamine incorporated in liposomes.

Popis výsledku anglicky

Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethal gamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time window (72h before and 48h after irradiation). L-AdDP significantly increased non-specific immunity against Candida albicans infectious model. L-AdDP could be therapeutically beneficial to moderate the haemopoietic damage and induce non-specific immunity to support the antimicrobial treatment of immunocompromised patients.Adamantyle dipeptide (AdDP) protect mice against irradiation when administered s.c. 24h before lethalgamma-irradiation. Incorporation of AdDP in liposomes (L-AdDP) significantly improved radioprotective effect of AdDP and recovery of the pool of granulocyte-macrophage haemopoietic progenitor cells (GM-CFC) in a broad application time wi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

<a href="/cs/project/PZ-Z2%2F25" target="_blank" >PZ-Z2/25: Imunofarmaka pro terapii a prevenci závažných onemocnění.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Immunopharmacology

ISSN

1567-5769

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

167-175

Kód UT WoS článku

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EID výsledku v databázi Scopus

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