Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F02%3A17023001" target="_blank" >RIV/68081707:_____/02:17023001 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027162:_____/02:90000008

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons.

Popis výsledku v původním jazyce

The removal cells from growth suppression via the inhibition of gap-junctional intercellular communication (GJIC) is supposed to contribute to tumor promotion. Inhibition of GJIC measured with an in vitro WB-F344 rat liver epithelial cell system was usedto assess the relative potencies of polycyclic aromatic hydrocarbons (PAHs) to inhibit GJIC. Although micromolar concentrations of PAHs were required to reach the inhibition level equal to the model tumor promoter phorbol 12-myristate 13-acetate twelveof the PAHs under study were found to be strong inhibitors of GJIC (strongest effects were observed at fluoranthene, picene, 5-methylchrysene and nine additional PAHs). Arbitrary values of inhibition equivalency factors (GJIC-IEFs) ranging from 0 (non-inhibiting PAHs) to 10.0 (strongest inhibitors), were suggested, suitable for the purposes of environmental risk assessment.

Název v anglickém jazyce

Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons.

Popis výsledku anglicky

The removal cells from growth suppression via the inhibition of gap-junctional intercellular communication (GJIC) is supposed to contribute to tumor promotion. Inhibition of GJIC measured with an in vitro WB-F344 rat liver epithelial cell system was usedto assess the relative potencies of polycyclic aromatic hydrocarbons (PAHs) to inhibit GJIC. Although micromolar concentrations of PAHs were required to reach the inhibition level equal to the model tumor promoter phorbol 12-myristate 13-acetate twelveof the PAHs under study were found to be strong inhibitors of GJIC (strongest effects were observed at fluoranthene, picene, 5-methylchrysene and nine additional PAHs). Arbitrary values of inhibition equivalency factors (GJIC-IEFs) ranging from 0 (non-inhibiting PAHs) to 10.0 (strongest inhibitors), were suggested, suitable for the purposes of environmental risk assessment.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicological Sciences

ISSN

1096-6080

e-ISSN

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Svazek periodika

65

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

43-51

Kód UT WoS článku

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EID výsledku v databázi Scopus

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