Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F03%3A17033128" target="_blank" >RIV/68081707:_____/03:17033128 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro.

Popis výsledku v původním jazyce

The effects of several synthetic adenosine receptor agonists on the growth characteristics of murine G:5:113 fibrosarcoma cells in vitro were evaluated. Cell number and viability, as well as proportions of cells in individual cell cycle phases, were determined after 48 h cultivation of the cells in the presence of concentrations of adenosine receptor agonists ranging between 0.01 and 500 muM. Effects of the non-selective adenosine receptor agonist NECA, as well as of agonists selective for A(1) (CPA), A(2A) (CGS 21680), and A(3) receptors (IB-MECA) were evaluated. A slight increase in cell number was observed at a narrow range of concentrations between 30-50 muM of NECA, which was reproduced by CPA, a selective A, receptor agonist, in concentrations ranging from 20-50 muM. The most important finding was that of significant inhibitory effects of adenosine receptor agonists on cell number in concentrations above 50 muM.

Název v anglickém jazyce

Effects of synthetic adenosine receptor agonists on growth characteristics of G:5:113 fibrosarcoma cells in vitro.

Popis výsledku anglicky

The effects of several synthetic adenosine receptor agonists on the growth characteristics of murine G:5:113 fibrosarcoma cells in vitro were evaluated. Cell number and viability, as well as proportions of cells in individual cell cycle phases, were determined after 48 h cultivation of the cells in the presence of concentrations of adenosine receptor agonists ranging between 0.01 and 500 muM. Effects of the non-selective adenosine receptor agonist NECA, as well as of agonists selective for A(1) (CPA), A(2A) (CGS 21680), and A(3) receptors (IB-MECA) were evaluated. A slight increase in cell number was observed at a narrow range of concentrations between 30-50 muM of NECA, which was reproduced by CPA, a selective A, receptor agonist, in concentrations ranging from 20-50 muM. The most important finding was that of significant inhibitory effects of adenosine receptor agonists on cell number in concentrations above 50 muM.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Drug Development Research

ISSN

0272-4391

e-ISSN

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Svazek periodika

60

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

303-311

Kód UT WoS článku

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EID výsledku v databázi Scopus

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