Dishevelled at the Crossroads of Pathways

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F14%3A00506830" target="_blank" >RIV/68081707:_____/14:00506830 - isvavai.cz</a>

Výsledek na webu

<a href="http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3407699&blobtype=pdf" target="_blank" >http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3407699&blobtype=pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/2045-3701-2-14" target="_blank" >10.1186/2045-3701-2-14</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dishevelled at the Crossroads of Pathways

Popis výsledku v původním jazyce

Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes thatngovern the formation of a complex multi-cellular organism. During growth and patterning, cells are specified bynboth quantitative and directional information. While quantitative information regulates cell proliferation andndifferentiation, directional information is conveyed in the form of cell polarities instructed by local and global cues.nMajor morphogens like Wnts play critical roles in embryonic development and they are also important innmaintaining tissue homeostasis. Abnormal regulation of these signaling events leads to a diverse array ofndevastating diseases including cancer. Wnts transduce their signals through several distinct pathways and theynregulate vertebrate embryonic development by providing both quantitative and directional information. Here,ntaking the developing skeletal system as an example, we review our work on Wnt signaling pathways in variousnaspects of development. We focus particularly on our most recent findings that showed that in vertebrates, Wnt5anacts as a global cue to establishing planar cell polarity (PCP). Our work suggests that Wnt morphogens regulatendevelopment by integrating quantitative and directional information. Our work also provides important insights inndisease like Robinow syndrome, brachydactyly type B1 (BDB1) and spina bifida, which can be caused by humannmutations in the Wnt/PCP signaling pathwa.

Název v anglickém jazyce

Dishevelled at the Crossroads of Pathways

Popis výsledku anglicky

Cell signaling mediated by morphogens is essential to coordinate growth and patterning, two key processes thatngovern the formation of a complex multi-cellular organism. During growth and patterning, cells are specified bynboth quantitative and directional information. While quantitative information regulates cell proliferation andndifferentiation, directional information is conveyed in the form of cell polarities instructed by local and global cues.nMajor morphogens like Wnts play critical roles in embryonic development and they are also important innmaintaining tissue homeostasis. Abnormal regulation of these signaling events leads to a diverse array ofndevastating diseases including cancer. Wnts transduce their signals through several distinct pathways and theynregulate vertebrate embryonic development by providing both quantitative and directional information. Here,ntaking the developing skeletal system as an example, we review our work on Wnt signaling pathways in variousnaspects of development. We focus particularly on our most recent findings that showed that in vertebrates, Wnt5anacts as a global cue to establishing planar cell polarity (PCP). Our work suggests that Wnt morphogens regulatendevelopment by integrating quantitative and directional information. Our work also provides important insights inndisease like Robinow syndrome, brachydactyly type B1 (BDB1) and spina bifida, which can be caused by humannmutations in the Wnt/PCP signaling pathwa.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

WNT SIGNALING IN DEVELOPMENT AND DISEASE: MOLECULAR MECHANISMS AND BIOLOGICAL FUNCTIONS

ISBN

978-1-118-44409-2

Počet stran výsledku

10

Strana od-do

—

Počet stran knihy

459

Název nakladatele

JOHN WILEY & SONS INC

Místo vydání

HOBOKEN

Kód UT WoS kapitoly

000348498000018