The evolutionary pathway of the staphylococcal cassette chromosome element
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00471943" target="_blank" >RIV/68081707:_____/16:00471943 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216224:14310/16:00088536
Výsledek na webu
<a href="http://dx.doi.org/10.1515/biolog-2016-0156" target="_blank" >http://dx.doi.org/10.1515/biolog-2016-0156</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/biolog-2016-0156" target="_blank" >10.1515/biolog-2016-0156</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The evolutionary pathway of the staphylococcal cassette chromosome element
Popis výsledku v původním jazyce
The staphylococcal cassette chromosome (SCC) element can carry resistance genes to antibiotics, disinfectants, and heavy metals, contributing to the survival of strains in the environment and causing difficulties in the treatment of staphylococcal infections. Methicillin resistance in staphylococci, which is of particular clinical significance, is encoded by staphylococcal cassette chromosome mec (SCCmec). Despite the importance of the SCC element and description of multiple nucleotide sequences, the information about its origin and evolution is still scarce. Here, we present a phylogenetic analysis of SCC elements that is unique in the use of whole SCC sequences. A phylogenetic tree for a noteworthy number of 81 SCC elements based on global sequence alignment was constructed. The SCC clustering did not reflect the genetic relationships of bacteria containing the SCC elements, but was done according to type, determined by the combination of mec gene complex class and ccr gene complex type. The results emphasise the horizontal gene transfer as a means of spread of SCC elements in bacterial strains. Overall, this study contributes to the understanding of SCC emergence, evolution, and dissemination.
Název v anglickém jazyce
The evolutionary pathway of the staphylococcal cassette chromosome element
Popis výsledku anglicky
The staphylococcal cassette chromosome (SCC) element can carry resistance genes to antibiotics, disinfectants, and heavy metals, contributing to the survival of strains in the environment and causing difficulties in the treatment of staphylococcal infections. Methicillin resistance in staphylococci, which is of particular clinical significance, is encoded by staphylococcal cassette chromosome mec (SCCmec). Despite the importance of the SCC element and description of multiple nucleotide sequences, the information about its origin and evolution is still scarce. Here, we present a phylogenetic analysis of SCC elements that is unique in the use of whole SCC sequences. A phylogenetic tree for a noteworthy number of 81 SCC elements based on global sequence alignment was constructed. The SCC clustering did not reflect the genetic relationships of bacteria containing the SCC elements, but was done according to type, determined by the combination of mec gene complex class and ccr gene complex type. The results emphasise the horizontal gene transfer as a means of spread of SCC elements in bacterial strains. Overall, this study contributes to the understanding of SCC emergence, evolution, and dissemination.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
BO - Biofyzika
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GP13-05069P" target="_blank" >GP13-05069P: Horizontální přenos stafylokokové chromozomové kazety mec (SCCmec) prostřednictvím bakteriofágů napříč kmeny rodu Staphylococcus</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Biologia
ISSN
0006-3088
e-ISSN
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Svazek periodika
71
Číslo periodika v rámci svazku
11
Stát vydavatele periodika
SK - Slovenská republika
Počet stran výsledku
9
Strana od-do
1195-1203
Kód UT WoS článku
000391882600001
EID výsledku v databázi Scopus
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