Recent progress in electrochemical sensors and assays for DNA damage and repair

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00471986" target="_blank" >RIV/68081707:_____/16:00471986 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/16:00088692 RIV/00216208:11310/16:10324241

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.trac.2015.11.018" target="_blank" >http://dx.doi.org/10.1016/j.trac.2015.11.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.trac.2015.11.018" target="_blank" >10.1016/j.trac.2015.11.018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Recent progress in electrochemical sensors and assays for DNA damage and repair

Popis výsledku v původním jazyce

DNA in cells is permanently exposed to endogenous or exogenous chemical or physical agents which may cause chemical changes in the DNA structure collectively called "DNA damage", which may have severe impacts on human health. Therefore, efficient techniques to detect DNA damage are sought, among which electroanalytical methods hold an important position. This review is focused on recent progress in the field of electrochemical sensors and assays for DNA damage, particularly on typical applications of advanced electrochemical techniques in detecting oxidative DNA damage, abasic lesions, base mismatches, non-covalent interactions with drugs and other substances. Special attention is paid to combinations of electrochemical detection with biochemical tools such as enzymatic systems mimicking metabolic activation of xenobiotics, or DNA repair enzymes converting specific nucleobase lesions to species offering more facile electrochemical detection. These applications create conditions for application of electroanalytical approaches in biological research, including studies of DNA repair processes. (C) 2015 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Recent progress in electrochemical sensors and assays for DNA damage and repair

Popis výsledku anglicky

DNA in cells is permanently exposed to endogenous or exogenous chemical or physical agents which may cause chemical changes in the DNA structure collectively called "DNA damage", which may have severe impacts on human health. Therefore, efficient techniques to detect DNA damage are sought, among which electroanalytical methods hold an important position. This review is focused on recent progress in the field of electrochemical sensors and assays for DNA damage, particularly on typical applications of advanced electrochemical techniques in detecting oxidative DNA damage, abasic lesions, base mismatches, non-covalent interactions with drugs and other substances. Special attention is paid to combinations of electrochemical detection with biochemical tools such as enzymatic systems mimicking metabolic activation of xenobiotics, or DNA repair enzymes converting specific nucleobase lesions to species offering more facile electrochemical detection. These applications create conditions for application of electroanalytical approaches in biological research, including studies of DNA repair processes. (C) 2015 Elsevier B.V. All rights reserved.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

<a href="/cs/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Centrum nových přístupů k bioanalýze a molekulární diagnostice</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Trac-Trends in Analytical Chemistry

ISSN

0165-9936

e-ISSN

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Svazek periodika

79

Číslo periodika v rámci svazku

MAY2016

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

160-167

Kód UT WoS článku

000376703900016

EID výsledku v databázi Scopus

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