Modification of Biomacromolecules with Six-valent Osmium Complexes and Electrochemical Analysis of the Modified Products

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00506501" target="_blank" >RIV/68081707:_____/18:00506501 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.researchgate.net/publication/329251891_Modification_of_bio_macromolecules_with_six-valent_osmium_complexes_and_electrochemical_analysis_of_the_modified_products" target="_blank" >https://www.researchgate.net/publication/329251891_Modification_of_bio_macromolecules_with_six-valent_osmium_complexes_and_electrochemical_analysis_of_the_modified_products</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Modification of Biomacromolecules with Six-valent Osmium Complexes and Electrochemical Analysis of the Modified Products

Popis výsledku v původním jazyce

This review is focused on the reaction of 1,2-diols with ligand complexes of six-valent osmium [Os(VI)L] (where L is a nitrogenous ligand) and possibilities of electrochemical analysis of yielded products. A number of biologically important molecules, such as mono-, oligo- and polysaccharides, RNA and glycoproteins, belong to compounds containing 1,2-diol in their structure. These compounds react with Os(VI) L yielding relatively stable ligand osmate esters which are electrochemically active and suitable to the electrochemical analysis. The ligand osmate esters give redox peaks at the mercury and carbon electrodes. The redox peaks are due to the electrochemical reduction or oxidation of osmium atoms. The osmate esters with some ligands give catalytic peaks at the mercury electrodes. The catalytic peak is due to the catalytic hydrogen evolution and is very sensitive. With the catalytic peak it is possible to measure picomolar concentrations in some cases. We have used reactions of Os(VI) L for the analysis of glycans and glycoproteins in relation to their great importance in biomedicine.

Název v anglickém jazyce

Modification of Biomacromolecules with Six-valent Osmium Complexes and Electrochemical Analysis of the Modified Products

Popis výsledku anglicky

This review is focused on the reaction of 1,2-diols with ligand complexes of six-valent osmium [Os(VI)L] (where L is a nitrogenous ligand) and possibilities of electrochemical analysis of yielded products. A number of biologically important molecules, such as mono-, oligo- and polysaccharides, RNA and glycoproteins, belong to compounds containing 1,2-diol in their structure. These compounds react with Os(VI) L yielding relatively stable ligand osmate esters which are electrochemically active and suitable to the electrochemical analysis. The ligand osmate esters give redox peaks at the mercury and carbon electrodes. The redox peaks are due to the electrochemical reduction or oxidation of osmium atoms. The osmate esters with some ligands give catalytic peaks at the mercury electrodes. The catalytic peak is due to the catalytic hydrogen evolution and is very sensitive. With the catalytic peak it is possible to measure picomolar concentrations in some cases. We have used reactions of Os(VI) L for the analysis of glycans and glycoproteins in relation to their great importance in biomedicine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemické listy

ISSN

0009-2770

e-ISSN

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Svazek periodika

112

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

590-597

Kód UT WoS článku

000447409400004

EID výsledku v databázi Scopus

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