Polynuclear Platinum Complexes. Structural Diversity and DNA Binding

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F18%3A00535937" target="_blank" >RIV/68081707:_____/18:00535937 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.degruyter.com/view/title/518384" target="_blank" >https://www.degruyter.com/view/title/518384</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/9783110470734-002" target="_blank" >10.1515/9783110470734-002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polynuclear Platinum Complexes. Structural Diversity and DNA Binding

Popis výsledku v původním jazyce

Polynuclear platinum complexes (PPCs) represent a discrete structural class of DNA-binding agents with excellent antitumor properties. The use of at least two platinum coordinating units automatically means that multifunctional DNA binding modes are possible. The structural variability inherent in a polynuclear platinum structure can be harnessed to produce discrete modes of DNA binding, with conformational changes distinct from and indeed inaccessible to, the mononuclear agents such as cisplatin. Since our original contributions in this field a wide variety of dinuclear complexes especially have been prepared, their DNA binding studied, and potential relevance to cytotoxicity examined. This chapter focuses on how DNA structure and reactivity is modulated through interactions with PPCs with emphasis on novel aspects of such structure and reactivity. How these major changes are further reflected in damaged DNA-protein binding and cellular effects are reviewed. We further review, for the first time, the great structural diversity achieved in PPC complex design and summarize their major DNA binding effects.

Název v anglickém jazyce

Polynuclear Platinum Complexes. Structural Diversity and DNA Binding

Popis výsledku anglicky

Polynuclear platinum complexes (PPCs) represent a discrete structural class of DNA-binding agents with excellent antitumor properties. The use of at least two platinum coordinating units automatically means that multifunctional DNA binding modes are possible. The structural variability inherent in a polynuclear platinum structure can be harnessed to produce discrete modes of DNA binding, with conformational changes distinct from and indeed inaccessible to, the mononuclear agents such as cisplatin. Since our original contributions in this field a wide variety of dinuclear complexes especially have been prepared, their DNA binding studied, and potential relevance to cytotoxicity examined. This chapter focuses on how DNA structure and reactivity is modulated through interactions with PPCs with emphasis on novel aspects of such structure and reactivity. How these major changes are further reflected in damaged DNA-protein binding and cellular effects are reviewed. We further review, for the first time, the great structural diversity achieved in PPC complex design and summarize their major DNA binding effects.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

METALLO-DRUGS: DEVELOPMENT AND ACTION OF ANTICANCER AGENTS

ISSN

1559-0836

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

2018

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

26

Strana od-do

43-68

Kód UT WoS článku

000471131700004

EID výsledku v databázi Scopus

2-s2.0-85049287331