Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir-III Complex Conjugated to a Far-Red Emitting Coumarin
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00510188" target="_blank" >RIV/68081707:_____/19:00510188 - isvavai.cz</a>
Výsledek na webu
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201901268" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201901268</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.201901268" target="_blank" >10.1002/anie.201901268</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir-III Complex Conjugated to a Far-Red Emitting Coumarin
Popis výsledku v původním jazyce
Although cyclometalated Ir-III complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated Ir-III complex conjugated to a far-red-emitting coumarin, Ir-III-COUPY, is reported with highly favourable properties for cancer phototherapy. Ir-III-COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.
Název v anglickém jazyce
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir-III Complex Conjugated to a Far-Red Emitting Coumarin
Popis výsledku anglicky
Although cyclometalated Ir-III complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated Ir-III complex conjugated to a far-red-emitting coumarin, Ir-III-COUPY, is reported with highly favourable properties for cancer phototherapy. Ir-III-COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10403 - Physical chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/GA18-09502S" target="_blank" >GA18-09502S: Ovlivnění rezistence nádorových buněk k chemoterapii s cílem obnovit jejich citlivost k novým, existujícím a dosud neúspěšným metalofarmakům</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Angewandte Chemie - International Edition
ISSN
1433-7851
e-ISSN
—
Svazek periodika
58
Číslo periodika v rámci svazku
19
Stát vydavatele periodika
DE - Spolková republika Německo
Počet stran výsledku
5
Strana od-do
6311-6315
Kód UT WoS článku
000471976400029
EID výsledku v databázi Scopus
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