DNA modification by cisplatin-like Pt(II) complexes containing 1,1 '-binaphtyl-2,2 '-diamine ligand does not correlate with their antiproliferative activity in cancer cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F19%3A00518335" target="_blank" >RIV/68081707:_____/19:00518335 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/19:73597237

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0020169319305912?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0020169319305912?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ica.2019.06.003" target="_blank" >10.1016/j.ica.2019.06.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

DNA modification by cisplatin-like Pt(II) complexes containing 1,1 '-binaphtyl-2,2 '-diamine ligand does not correlate with their antiproliferative activity in cancer cells

Popis výsledku v původním jazyce

DNA-reactive platinum complexes, such as cisplatin and its antitumor derivatives, are presupposed to kill actively proliferating cancer cells. Thus, the intense research of the mechanism of action (MoA) of this class of platinum drugs led to the conclusion that a major factor responsible for antitumor effects of conventional platinum drugs and their derivatives is DNA damage induced by their coordinative binding. Here, we present the results of the investigations aimed at clarification of the DNA binding modes of two direct derivatives of cisplatin, such as enantiomeric Pt(II) complexes, R- and S-1,1'-binaphthyl-2,2'-diaminodichlorido-Pt(II) complexes (R- and S[Pt(DABN)Cl-2]), and compared these modes to that of cisplatin. We show that the chirality of [Pt(DABN)Cl-2] complexes can markedly affect their DNA binding mode. On the other hand, the variations in DNA binding do not translate directly into cellular processing and toxicity in cancer cells. Thus, the results are consistent with the view and support the hypothesis that, in contrast to conventional platinum drugs and their derivatives, the DNA damage resulting from the binding of the [Pt(DABN)Cl-2] complexes is not a major factor accountable for their biological actions.

Název v anglickém jazyce

DNA modification by cisplatin-like Pt(II) complexes containing 1,1 '-binaphtyl-2,2 '-diamine ligand does not correlate with their antiproliferative activity in cancer cells

Popis výsledku anglicky

DNA-reactive platinum complexes, such as cisplatin and its antitumor derivatives, are presupposed to kill actively proliferating cancer cells. Thus, the intense research of the mechanism of action (MoA) of this class of platinum drugs led to the conclusion that a major factor responsible for antitumor effects of conventional platinum drugs and their derivatives is DNA damage induced by their coordinative binding. Here, we present the results of the investigations aimed at clarification of the DNA binding modes of two direct derivatives of cisplatin, such as enantiomeric Pt(II) complexes, R- and S-1,1'-binaphthyl-2,2'-diaminodichlorido-Pt(II) complexes (R- and S[Pt(DABN)Cl-2]), and compared these modes to that of cisplatin. We show that the chirality of [Pt(DABN)Cl-2] complexes can markedly affect their DNA binding mode. On the other hand, the variations in DNA binding do not translate directly into cellular processing and toxicity in cancer cells. Thus, the results are consistent with the view and support the hypothesis that, in contrast to conventional platinum drugs and their derivatives, the DNA damage resulting from the binding of the [Pt(DABN)Cl-2] complexes is not a major factor accountable for their biological actions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/GA18-09502S" target="_blank" >GA18-09502S: Ovlivnění rezistence nádorových buněk k chemoterapii s cílem obnovit jejich citlivost k novým, existujícím a dosud neúspěšným metalofarmakům</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganica chimica acta

ISSN

0020-1693

e-ISSN

—

Svazek periodika

495

Číslo periodika v rámci svazku

SEP 1 2019

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

118952

Kód UT WoS článku

000481728800021

EID výsledku v databázi Scopus

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