Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00537740" target="_blank" >RIV/68081707:_____/20:00537740 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11310/20:10415751 RIV/61989592:15310/20:73603656
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0277538720303296?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0277538720303296?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.poly.2020.114672" target="_blank" >10.1016/j.poly.2020.114672</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells
Popis výsledku v původním jazyce
Three gallium(III) complexes, [Ga(NQ)(3)] (1), Na-3[Ga(SQ)(3)]center dot 7H(2)O center dot 3NaCl (2) and [Ga(CINQ)(3)]center dot MeOH (3) were synthesised as possible anticancer agents (H-NQ= 5-nitro-8-quinolinol, H-SQH = 5-sulfo-8-quinolinol, H-CINQ= 5-chloro-7-nitro-8-quinolinol) and characterised by elemental analysis, IR and NMR spectroscopy. Single crystal structure analysis of 1 revealed two crystallographically independent [Ga(NQ)(3)] molecules in the asymmetric part of the unit cell. Stability of the complexes 1 and 2 in solution was determined by H-1 NMR spectroscopy. Complex 3 was not further studied due to the low solubility. Antiproliferative activity of complexes 1 and 2 was studied using in vitro MIT assay against the A2780, HCT116 and MDA-MB-231 cancer cell lines and the selectivity of the complexes was verified on non-cancerous MRCS pd30 cell line. Complex 1 showed high antiproliferative potency (IC50 = 3.6 +/- 0.8 mu M for HCT116) and noticeable selectivity of 1 against the cancer cell lines (IC50 = 32 +/- 4 mu M for normal MRCS pd30 cell line) was also found. The complex 2 displayed the highest antioxidant activity of all tested complexes and free ligands. (C) 2020 Elsevier Ltd. All rights reserved.
Název v anglickém jazyce
Low-dimensional compounds containing bioactive ligands. Part XV: Antiproliferative activity of tris(5-nitro-8-quinolinolato)gallium(III) complex with noticeable selectivity against the cancerous cells
Popis výsledku anglicky
Three gallium(III) complexes, [Ga(NQ)(3)] (1), Na-3[Ga(SQ)(3)]center dot 7H(2)O center dot 3NaCl (2) and [Ga(CINQ)(3)]center dot MeOH (3) were synthesised as possible anticancer agents (H-NQ= 5-nitro-8-quinolinol, H-SQH = 5-sulfo-8-quinolinol, H-CINQ= 5-chloro-7-nitro-8-quinolinol) and characterised by elemental analysis, IR and NMR spectroscopy. Single crystal structure analysis of 1 revealed two crystallographically independent [Ga(NQ)(3)] molecules in the asymmetric part of the unit cell. Stability of the complexes 1 and 2 in solution was determined by H-1 NMR spectroscopy. Complex 3 was not further studied due to the low solubility. Antiproliferative activity of complexes 1 and 2 was studied using in vitro MIT assay against the A2780, HCT116 and MDA-MB-231 cancer cell lines and the selectivity of the complexes was verified on non-cancerous MRCS pd30 cell line. Complex 1 showed high antiproliferative potency (IC50 = 3.6 +/- 0.8 mu M for HCT116) and noticeable selectivity of 1 against the cancer cell lines (IC50 = 32 +/- 4 mu M for normal MRCS pd30 cell line) was also found. The complex 2 displayed the highest antioxidant activity of all tested complexes and free ligands. (C) 2020 Elsevier Ltd. All rights reserved.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10402 - Inorganic and nuclear chemistry
Návaznosti výsledku
Projekt
<a href="/cs/project/GA18-09502S" target="_blank" >GA18-09502S: Ovlivnění rezistence nádorových buněk k chemoterapii s cílem obnovit jejich citlivost k novým, existujícím a dosud neúspěšným metalofarmakům</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Polyhedron
ISSN
0277-5387
e-ISSN
—
Svazek periodika
187
Číslo periodika v rámci svazku
2020
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
114672
Kód UT WoS článku
000556764100028
EID výsledku v databázi Scopus
2-s2.0-85086725258