Synthesis and characterization of (Ru(II), Co(III)) heterobimetallic complexes formed with a 1,10-phenanthroline based hydroxamic acid conjugate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F20%3A00539536" target="_blank" >RIV/68081707:_____/20:00539536 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/20:73603655

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0022328X20301674?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022328X20301674?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jorganchem.2020.121265" target="_blank" >10.1016/j.jorganchem.2020.121265</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and characterization of (Ru(II), Co(III)) heterobimetallic complexes formed with a 1,10-phenanthroline based hydroxamic acid conjugate

Popis výsledku v původním jazyce

A novel ambidentate type hydroxamic acid derivative (phenhaH, 1) containing an (O,O) and a 1,10-phenantroline (phen) based (N,N) donoratom set together with its heterobimetallic complexes incorporating an octahedral [Co(4 N)](3+) (4 N = tris(2-aminoethyl)amine (tren) or tris(2-methylpyridyl)amine (tpa)) and a half-sandwich type [(eta(6)-p-cym)Ru](2+) entity have been synthesized and characterized using various analytical techniques. Reaction of [Co(4 N)Cl]Cl-2 with 1 proved the exclusive (O,O) coordination of the ligand to the [Co( 4 N)](3+) core to yield [Co(tpa)(phenha)](ClO4)(2), (2). Subsequent treatment of 1 with [Ru(eta(6)-p-cym)Cl-2](2) and [Co(4 N)Cl]Cl-2 in a one-pot reaction resulted in the formation of [(eta(6)-p-cym)Ru(Cl)(phenha)Co(tren)]Cl(PF6)(2) (3) and [(eta(6)-p-cym)Ru(Cl)(phenha)Co(tpa)](PF6)(3) (4) in which the organometallic Ru core is coordinated by the phen part while the Co entity by the hydroxamate part of 1. Cyclic voltammetry revealed that 4 could be reduced at a less negative potential and exhibits a reversible Co(III)/Co(II) redox process compared to 3 due to the pi-back bonding interaction between the Co(III) centre and the pyridyl-N donors of tpa in 4. Complexes 2-4 were tested for their in vitro cytotoxicity using human-derived cancer cell lines (HeLa, MCF-7, HCT116 and MDA-MB-231) and showed moderate anti-proliferative activity in the double digit micromolar concentration range, 4 being the most active. Complex 4 displayed better activity against MDA-MB-231 cells than cisplatin. (C) 2020 The Authors. Published by Elsevier B.V.

Název v anglickém jazyce

Synthesis and characterization of (Ru(II), Co(III)) heterobimetallic complexes formed with a 1,10-phenanthroline based hydroxamic acid conjugate

Popis výsledku anglicky

A novel ambidentate type hydroxamic acid derivative (phenhaH, 1) containing an (O,O) and a 1,10-phenantroline (phen) based (N,N) donoratom set together with its heterobimetallic complexes incorporating an octahedral [Co(4 N)](3+) (4 N = tris(2-aminoethyl)amine (tren) or tris(2-methylpyridyl)amine (tpa)) and a half-sandwich type [(eta(6)-p-cym)Ru](2+) entity have been synthesized and characterized using various analytical techniques. Reaction of [Co(4 N)Cl]Cl-2 with 1 proved the exclusive (O,O) coordination of the ligand to the [Co( 4 N)](3+) core to yield [Co(tpa)(phenha)](ClO4)(2), (2). Subsequent treatment of 1 with [Ru(eta(6)-p-cym)Cl-2](2) and [Co(4 N)Cl]Cl-2 in a one-pot reaction resulted in the formation of [(eta(6)-p-cym)Ru(Cl)(phenha)Co(tren)]Cl(PF6)(2) (3) and [(eta(6)-p-cym)Ru(Cl)(phenha)Co(tpa)](PF6)(3) (4) in which the organometallic Ru core is coordinated by the phen part while the Co entity by the hydroxamate part of 1. Cyclic voltammetry revealed that 4 could be reduced at a less negative potential and exhibits a reversible Co(III)/Co(II) redox process compared to 3 due to the pi-back bonding interaction between the Co(III) centre and the pyridyl-N donors of tpa in 4. Complexes 2-4 were tested for their in vitro cytotoxicity using human-derived cancer cell lines (HeLa, MCF-7, HCT116 and MDA-MB-231) and showed moderate anti-proliferative activity in the double digit micromolar concentration range, 4 being the most active. Complex 4 displayed better activity against MDA-MB-231 cells than cisplatin. (C) 2020 The Authors. Published by Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/GA18-09502S" target="_blank" >GA18-09502S: Ovlivnění rezistence nádorových buněk k chemoterapii s cílem obnovit jejich citlivost k novým, existujícím a dosud neúspěšným metalofarmakům</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Organometallic Chemistry

ISSN

0022-328X

e-ISSN

—

Svazek periodika

916

Číslo periodika v rámci svazku

JUN 14 2020

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

121265

Kód UT WoS článku

000537690200011

EID výsledku v databázi Scopus

2-s2.0-85082869532