Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00574516" target="_blank" >RIV/68081707:_____/23:00574516 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00586" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00586</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jmedchem.3c00586" target="_blank" >10.1021/acs.jmedchem.3c00586</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells

Popis výsledku v původním jazyce

Herein, we report a series of new octahedral iridium(III)complexes Ir1-Ir9 of the type [Ir(N<^>N<^>N)(C<^>N)Cl]PF6 (N<^>N<^>N = 4 & PRIME,-(p-tolyl)-2,2 & PRIME,:6 & PRIME,,2 & DPRIME,-terpyridine,C<^>N = deprotonated 2-arylbenzimidazole backbone) to introduce newmetal-based compounds for effective inhibition of metastatic processesin triple-negative breast cancer (TNBC). The results show that thestructural modifications within the C<^>N scaffold strongly impact theantimetastatic properties of these complexes in TNBC cells. Furthermore,testing the antimetastatic effects of the investigated Ir complexesrevealed that the highest antimetastatic activity in TNBC cells isexhibited by complex Ir1. This result was in contrastto the effects of the clinically used drug doxorubicin used in conventionalchemotherapy of TNBC, which conversely promoted metastatic propertiesof TNBC cells. Thus, the latter result suggests that doxorubicin chemotherapymay increase the risk of metastasis of breast cancer cells, so thesearch for new drugs to treat breast cancer that would show betterantitumor effects than doxorubicin is justified.

Název v anglickém jazyce

Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells

Popis výsledku anglicky

Herein, we report a series of new octahedral iridium(III)complexes Ir1-Ir9 of the type [Ir(N<^>N<^>N)(C<^>N)Cl]PF6 (N<^>N<^>N = 4 & PRIME,-(p-tolyl)-2,2 & PRIME,:6 & PRIME,,2 & DPRIME,-terpyridine,C<^>N = deprotonated 2-arylbenzimidazole backbone) to introduce newmetal-based compounds for effective inhibition of metastatic processesin triple-negative breast cancer (TNBC). The results show that thestructural modifications within the C<^>N scaffold strongly impact theantimetastatic properties of these complexes in TNBC cells. Furthermore,testing the antimetastatic effects of the investigated Ir complexesrevealed that the highest antimetastatic activity in TNBC cells isexhibited by complex Ir1. This result was in contrastto the effects of the clinically used drug doxorubicin used in conventionalchemotherapy of TNBC, which conversely promoted metastatic propertiesof TNBC cells. Thus, the latter result suggests that doxorubicin chemotherapymay increase the risk of metastasis of breast cancer cells, so thesearch for new drugs to treat breast cancer that would show betterantitumor effects than doxorubicin is justified.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/GA23-06307S" target="_blank" >GA23-06307S: Sloučeniny na bázi kovů jako kandidáti pro antimetastatickou chemoterapii</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Medicinal Chemistry

ISSN

0022-2623

e-ISSN

1520-4804

Svazek periodika

66

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

18

Strana od-do

9766-9783

Kód UT WoS článku

001023572900001

EID výsledku v databázi Scopus

2-s2.0-85164689399