Prebiotic Synthesis of 3',5'-Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide-Assisted Cyclization

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00583702" target="_blank" >RIV/68081707:_____/23:00583702 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15310/23:73620885 RIV/61989592:15640/23:73620885 RIV/61989100:27740/23:10253164
Výsledek na webu
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300510" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300510</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cbic.202300510" target="_blank" >10.1002/cbic.202300510</a>

Jazyk výsledku
angličtina
Název v původním jazyce
Prebiotic Synthesis of 3',5'-Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide-Assisted Cyclization
Popis výsledku v původním jazyce
3',5'-Cyclic nucleotides play a fundamental role in modern biochemical processes and have been suggested to have played a central role at the origin of terrestrial life. In this work, we suggest that a formamide-based systems chemistry might account for their availability on the early Earth. In particular, we demonstrate that in a liquid formamide environment at elevated temperatures 3',5'-cyclic nucleotides are obtained in good yield and selectivity upon intramolecular cyclization of 5'-phosphorylated nucleosides in the presence of carbodiimides.
Název v anglickém jazyce
Prebiotic Synthesis of 3',5'-Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide-Assisted Cyclization
Popis výsledku anglicky
3',5'-Cyclic nucleotides play a fundamental role in modern biochemical processes and have been suggested to have played a central role at the origin of terrestrial life. In this work, we suggest that a formamide-based systems chemistry might account for their availability on the early Earth. In particular, we demonstrate that in a liquid formamide environment at elevated temperatures 3',5'-cyclic nucleotides are obtained in good yield and selectivity upon intramolecular cyclization of 5'-phosphorylated nucleosides in the presence of carbodiimides.

Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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