Interaction of dinuclear Co(III) cylinders with higher-order DNA structures
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00587206" target="_blank" >RIV/68081707:_____/24:00587206 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15310/24:73626621
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0009279724001777?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009279724001777?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbi.2024.111031" target="_blank" >10.1016/j.cbi.2024.111031</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Interaction of dinuclear Co(III) cylinders with higher-order DNA structures
Popis výsledku v původním jazyce
Alternative DNA structures play critical roles in fundamental biological processes linked to human diseases. Thus, targeting and stabilizing these structures by specific ligands could affect the progression of cancer and other diseases. Here, we describe, using methods of molecular biophysics, the interactions of two oxidatively locked [Co2L3]6+ cylinders, rac-2 and meso-1, with diverse alternative DNA structures, such as junctions, G quadruplexes, and bulges. This study was motivated by earlier results demonstrating that both Co(III) cylinders exhibit potent and selective activity against cancer cells, accumulate in the nucleus of cancer cells, and prove to be efficient DNA binders. The results show that the bigger cylinder rac-2 stabilizes all DNA structures, while the smaller cylinder meso-1 stabilizes just the Y-shaped three-way junctions. Collectively, the results of this study suggest that the stabilization of alternative DNA structures by Co(III) cylinders investigated in this work might contribute to the mechanism of their biological activity.
Název v anglickém jazyce
Interaction of dinuclear Co(III) cylinders with higher-order DNA structures
Popis výsledku anglicky
Alternative DNA structures play critical roles in fundamental biological processes linked to human diseases. Thus, targeting and stabilizing these structures by specific ligands could affect the progression of cancer and other diseases. Here, we describe, using methods of molecular biophysics, the interactions of two oxidatively locked [Co2L3]6+ cylinders, rac-2 and meso-1, with diverse alternative DNA structures, such as junctions, G quadruplexes, and bulges. This study was motivated by earlier results demonstrating that both Co(III) cylinders exhibit potent and selective activity against cancer cells, accumulate in the nucleus of cancer cells, and prove to be efficient DNA binders. The results show that the bigger cylinder rac-2 stabilizes all DNA structures, while the smaller cylinder meso-1 stabilizes just the Y-shaped three-way junctions. Collectively, the results of this study suggest that the stabilization of alternative DNA structures by Co(III) cylinders investigated in this work might contribute to the mechanism of their biological activity.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
<a href="/cs/project/GA24-10213S" target="_blank" >GA24-10213S: Poškození DNA v nádorových buňkách v důsledku stabilizace alternativních struktur DNA specifickými ligandy. Vztah k jejich protinádorové aktivitě.</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Chemico-Biological Interactions
ISSN
0009-2797
e-ISSN
1872-7786
Svazek periodika
395
Číslo periodika v rámci svazku
may 2024
Stát vydavatele periodika
IE - Irsko
Počet stran výsledku
8
Strana od-do
111031
Kód UT WoS článku
001240948700001
EID výsledku v databázi Scopus
2-s2.0-85192741218