A collateral circulation in ischemic stroke accelerates recanalization due to lower clot compaction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F24%3A00602572" target="_blank" >RIV/68081707:_____/24:00602572 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00137823 RIV/00159816:_____/24:00081427

Výsledek na webu

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0314079" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0314079</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0314079" target="_blank" >10.1371/journal.pone.0314079</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A collateral circulation in ischemic stroke accelerates recanalization due to lower clot compaction

Popis výsledku v původním jazyce

Collaterals improve recanalization in acute ischemic stroke patients treated with intravenous thrombolysis, but the mechanisms are poorly understood. To investigate it, an in vitro flow model of the middle cerebral artery was developed with or without collaterals. An occlusion was achieved using human blood clots. Recanalization time, thrombolysis (clot length decrease and red blood cell (RBC) release), pressure gradient across the clot and clot compaction were measured. Results showed that with or without collateral alteplase-treated RBC dominant clots showed recanalization time 98 +/- 23 min vs 130 +/- 35 min (difference 32 min, 95% CI6-58 min), relative clot reduction 31.8 +/- 14.9% vs 30.3 +/- 13.2% (difference 1.5%, 95% CI 10.4-13.4%) and RBC release 0.30 +/- 0.07 vs 0.27 +/- 0.09 (difference 0.03, 95% CI 0.04-0.10). Similar results were observed with fibrin-dominant clots. In RBC dominant clots, the presence vs absence of collateral caused different pressure gradients across the clot 0.41 +/- 0.09 vs 0.70 +/- 0.09 mmHg (difference 0.29 mmHg, 95% CI0.17-0.41 mmHg), and caused the reduction of initial clot compaction by 5%. These findings align with observations in patients, where collaterals shortened recanalization time. However, collaterals did not increase thrombolysis. Instead, they decreased the pressure gradient across the clot, resulting in less clot compaction and easier distal displacement of the clot.

Název v anglickém jazyce

A collateral circulation in ischemic stroke accelerates recanalization due to lower clot compaction

Popis výsledku anglicky

Collaterals improve recanalization in acute ischemic stroke patients treated with intravenous thrombolysis, but the mechanisms are poorly understood. To investigate it, an in vitro flow model of the middle cerebral artery was developed with or without collaterals. An occlusion was achieved using human blood clots. Recanalization time, thrombolysis (clot length decrease and red blood cell (RBC) release), pressure gradient across the clot and clot compaction were measured. Results showed that with or without collateral alteplase-treated RBC dominant clots showed recanalization time 98 +/- 23 min vs 130 +/- 35 min (difference 32 min, 95% CI6-58 min), relative clot reduction 31.8 +/- 14.9% vs 30.3 +/- 13.2% (difference 1.5%, 95% CI 10.4-13.4%) and RBC release 0.30 +/- 0.07 vs 0.27 +/- 0.09 (difference 0.03, 95% CI 0.04-0.10). Similar results were observed with fibrin-dominant clots. In RBC dominant clots, the presence vs absence of collateral caused different pressure gradients across the clot 0.41 +/- 0.09 vs 0.70 +/- 0.09 mmHg (difference 0.29 mmHg, 95% CI0.17-0.41 mmHg), and caused the reduction of initial clot compaction by 5%. These findings align with observations in patients, where collaterals shortened recanalization time. However, collaterals did not increase thrombolysis. Instead, they decreased the pressure gradient across the clot, resulting in less clot compaction and easier distal displacement of the clot.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30502 - Other medical science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

1932-6203

Svazek periodika

19

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

e0314079

Kód UT WoS článku

001360846500006

EID výsledku v databázi Scopus

2-s2.0-85209911131