One-step fabrication of chitosan/dialdehyde cellulose/polypyrrole composite nanofibers with antibacterial, antioxidant, and immunomodulatory effects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F25%3A00635565" target="_blank" >RIV/68081707:_____/25:00635565 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28110/25:63594681 RIV/70883521:28610/25:63594681

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0141813025026571?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0141813025026571?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijbiomac.2025.142105" target="_blank" >10.1016/j.ijbiomac.2025.142105</a>

Jazyk výsledku

angličtina

Název v původním jazyce

One-step fabrication of chitosan/dialdehyde cellulose/polypyrrole composite nanofibers with antibacterial, antioxidant, and immunomodulatory effects

Popis výsledku v původním jazyce

The study introduces a novel method for fabricating crosslinked chitosan/polypyrrole (PPy) composite nano- fibers with covalently anchored PPy. Crosslinking is achieved already during electrospinning by using dialdehyde cellulose (DAC) as a dual-functioning reagent able to simultaneously crosslink chitosan nanofibers and covalently tether PPy nanoparticles by a newly discovered aldol condensation reaction. The presented method eliminates the need for postprocessing steps. It reduces the environmental impact by avoiding toxic organic chemicals while preventing PPy leaching and improving prepared composite nanofibers' mechanical and biological properties. A direct comparison to neat chitosan nanofibres was performed to demonstrate the superiority of prepared composites. The resulting crosslinked CHIT_DAC_PPy composite nanofibers have increased tensile strength, improved stability at low pH, conductivity up to 11 mS/cm, and higher swelling compared to neat CHIT nanofibers. They also possess significantly enhanced antibacterial activity against gram-positive S. aureus, higher antioxidant activity, increased immunomodulatory effects, and substantially higher acceleration of wound healing in vitro. CHIT_DAC_PPy nanofibrous composite thus shows significant potential for fabricating advanced wound dressings.

Název v anglickém jazyce

One-step fabrication of chitosan/dialdehyde cellulose/polypyrrole composite nanofibers with antibacterial, antioxidant, and immunomodulatory effects

Popis výsledku anglicky

The study introduces a novel method for fabricating crosslinked chitosan/polypyrrole (PPy) composite nano- fibers with covalently anchored PPy. Crosslinking is achieved already during electrospinning by using dialdehyde cellulose (DAC) as a dual-functioning reagent able to simultaneously crosslink chitosan nanofibers and covalently tether PPy nanoparticles by a newly discovered aldol condensation reaction. The presented method eliminates the need for postprocessing steps. It reduces the environmental impact by avoiding toxic organic chemicals while preventing PPy leaching and improving prepared composite nanofibers' mechanical and biological properties. A direct comparison to neat chitosan nanofibres was performed to demonstrate the superiority of prepared composites. The resulting crosslinked CHIT_DAC_PPy composite nanofibers have increased tensile strength, improved stability at low pH, conductivity up to 11 mS/cm, and higher swelling compared to neat CHIT nanofibers. They also possess significantly enhanced antibacterial activity against gram-positive S. aureus, higher antioxidant activity, increased immunomodulatory effects, and substantially higher acceleration of wound healing in vitro. CHIT_DAC_PPy nanofibrous composite thus shows significant potential for fabricating advanced wound dressings.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GA24-11534S" target="_blank" >GA24-11534S: Vodivé (bio)polymerní kompozity s kovalentně vázaným polypyrrolem pro biomedicínské aplikace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Biological Macromolecules

ISSN

0141-8130

e-ISSN

1879-0003

Svazek periodika

308

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

142105

Kód UT WoS článku

001457068600001

EID výsledku v databázi Scopus

2-s2.0-105000702121