Simulation-based design of a microfabricated pneumatic electrospray nebulizer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081715%3A_____%2F15%3A00434464" target="_blank" >RIV/68081715:_____/15:00434464 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/15:00080741

Výsledek na webu

<a href="http://dx.doi.org/10.1002/elps.201400387" target="_blank" >http://dx.doi.org/10.1002/elps.201400387</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201400387" target="_blank" >10.1002/elps.201400387</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Simulation-based design of a microfabricated pneumatic electrospray nebulizer

Popis výsledku v původním jazyce

A microfabricated pneumatic electrospray nebulizer has been developed and evaluated using computer simulations and experimental measurements of the mass spectrometry signals. The microdevice under development is designed for electrospray mass spectrometry interfacing without the need to fabricate an electrospray needle and can be used as a disposable or an integral part of a reusable system. The design of the chip layout was supported by computational fluid dynamics simulations. The tested microdeviceswere fabricated in glass using conventional photolithography, followed by wet chemical etching and thermal bonding. The performance of the microfabricated nebulizer was evaluated by means of time-of-flight mass spectrometry with a peptide mixture. It wasdemonstrated that the nebulizer, operating at supersonic speed of the nebulizing gas, produced very stable nanospray (900 nl/min) as documented by less than 0.1 % (standard error) fluctuation in total mass spectrometric signal intensity.

Název v anglickém jazyce

Simulation-based design of a microfabricated pneumatic electrospray nebulizer

Popis výsledku anglicky

A microfabricated pneumatic electrospray nebulizer has been developed and evaluated using computer simulations and experimental measurements of the mass spectrometry signals. The microdevice under development is designed for electrospray mass spectrometry interfacing without the need to fabricate an electrospray needle and can be used as a disposable or an integral part of a reusable system. The design of the chip layout was supported by computational fluid dynamics simulations. The tested microdeviceswere fabricated in glass using conventional photolithography, followed by wet chemical etching and thermal bonding. The performance of the microfabricated nebulizer was evaluated by means of time-of-flight mass spectrometry with a peptide mixture. It wasdemonstrated that the nebulizer, operating at supersonic speed of the nebulizing gas, produced very stable nanospray (900 nl/min) as documented by less than 0.1 % (standard error) fluctuation in total mass spectrometric signal intensity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electrophoresis

ISSN

0173-0835

e-ISSN

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Svazek periodika

36

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

386-392

Kód UT WoS článku

000349220500003

EID výsledku v databázi Scopus

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