Exploring the toxicity of mononuclear piano-stool Ru(II) anticancer agents: A comprehensive literature review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081723%3A_____%2F25%3A00637246" target="_blank" >RIV/68081723:_____/25:00637246 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0010854525004722?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0010854525004722?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccr.2025.216902" target="_blank" >10.1016/j.ccr.2025.216902</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exploring the toxicity of mononuclear piano-stool Ru(II) anticancer agents: A comprehensive literature review

Popis výsledku v původním jazyce

Piano-stool Ru(II) complexes have emerged as a promising class of anticancer agents characterized by structural modularity and diverse cytotoxic activities. The present review consolidates over three decades of research, analyzing IC50 data for 1,449 mononuclear Ru(II) compounds across 151 cancer and healthy cell lines. The whole dataset reveals structure-activity relationships (SAR), emphasizing the role of multidentate ligands – particularly NN-, NO-, and OO-types – and ηn-rings in modulating the biological activity. Compounds with cyclopentadienyl groups often exhibit remarkable effectiveness, achieving sub-micromolar IC50 values and demonstrating efficacy against drug-resistant cancer lines. The bibliographic analysis highlights the versatility of certain ligand combinations, particularly triphenylphosphane with mono- and bidentate ligands, including bipyridine or thioacetamide motifs, which drive exceptional cytotoxic properties. Despite the extensive data set, some gaps remain as some cancer types are underrepresented, and the mechanism(s) of action of the Ru(II)-based cytotoxic agents is(are) not yet fully understood. Future possible research directions within this remarkable family of mononuclear half-sandwich Ru(II) complexes are given.

Název v anglickém jazyce

Exploring the toxicity of mononuclear piano-stool Ru(II) anticancer agents: A comprehensive literature review

Popis výsledku anglicky

Piano-stool Ru(II) complexes have emerged as a promising class of anticancer agents characterized by structural modularity and diverse cytotoxic activities. The present review consolidates over three decades of research, analyzing IC50 data for 1,449 mononuclear Ru(II) compounds across 151 cancer and healthy cell lines. The whole dataset reveals structure-activity relationships (SAR), emphasizing the role of multidentate ligands – particularly NN-, NO-, and OO-types – and ηn-rings in modulating the biological activity. Compounds with cyclopentadienyl groups often exhibit remarkable effectiveness, achieving sub-micromolar IC50 values and demonstrating efficacy against drug-resistant cancer lines. The bibliographic analysis highlights the versatility of certain ligand combinations, particularly triphenylphosphane with mono- and bidentate ligands, including bipyridine or thioacetamide motifs, which drive exceptional cytotoxic properties. Despite the extensive data set, some gaps remain as some cancer types are underrepresented, and the mechanism(s) of action of the Ru(II)-based cytotoxic agents is(are) not yet fully understood. Future possible research directions within this remarkable family of mononuclear half-sandwich Ru(II) complexes are given.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/EH22_008%2F0004596" target="_blank" >EH22_008/0004596: Senzory a detektory pro informační společnost budoucnosti</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Coordination Chemistry Reviews

ISSN

0010-8545

e-ISSN

1873-3840

Svazek periodika

543

Číslo periodika v rámci svazku

NOV

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

25

Strana od-do

216902

Kód UT WoS článku

001529348300004

EID výsledku v databázi Scopus

2-s2.0-105009771534