Connectivity of epileptic brain regions in wake and sleep

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F15%3A00452078" target="_blank" >RIV/68081731:_____/15:00452078 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26220/15:PU116786

Výsledek na webu

<a href="http://dx.doi.org/10.1109/EMBC.2015.7318825" target="_blank" >http://dx.doi.org/10.1109/EMBC.2015.7318825</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/EMBC.2015.7318825" target="_blank" >10.1109/EMBC.2015.7318825</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Connectivity of epileptic brain regions in wake and sleep

Popis výsledku v původním jazyce

Focal epileptic brain is characterized by a region of pathological tissue seizure onset zone (SOZ) - the pathologic tissue generating seizures. During the interictal period (nonseizure) the SOZ is characterized by epileptiform activity - interictal spikes & high-frequency oscillations (HFO). The SOZ also exhibits hyper-synchrony and functional disconnection from the surrounding areas. Recent studies have described the synchrony inside the SOZ and surrounding tissue for just small sets of patients (2-4)and without any distinction in behavioral states. Wake and sleep cycles can, however, have a significant influence on SOZ activity. Here we show the results of connectivity analysis in three fundamental areas of the epileptic brain - inside SOZ, outsideSOZ and bridging areas in 7 patients during wake and sleep. We observed increased synchrony inside SOZ and decreased synchrony on its edges (bridging areas) in specific frequency bands. We also detected significant differences of synchron

Název v anglickém jazyce

Connectivity of epileptic brain regions in wake and sleep

Popis výsledku anglicky

Focal epileptic brain is characterized by a region of pathological tissue seizure onset zone (SOZ) - the pathologic tissue generating seizures. During the interictal period (nonseizure) the SOZ is characterized by epileptiform activity - interictal spikes & high-frequency oscillations (HFO). The SOZ also exhibits hyper-synchrony and functional disconnection from the surrounding areas. Recent studies have described the synchrony inside the SOZ and surrounding tissue for just small sets of patients (2-4)and without any distinction in behavioral states. Wake and sleep cycles can, however, have a significant influence on SOZ activity. Here we show the results of connectivity analysis in three fundamental areas of the epileptic brain - inside SOZ, outsideSOZ and bridging areas in 7 patients during wake and sleep. We observed increased synchrony inside SOZ and decreased synchrony on its edges (bridging areas) in specific frequency bands. We also detected significant differences of synchron

Druh

D - Stať ve sborníku

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE

ISBN

978-1-4244-9270-1

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

2191-2194

Název nakladatele

IEEE

Místo vydání

Piscataway

Místo konání akce

Milano

Datum konání akce

25. 8. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—