Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F17%3A00480406" target="_blank" >RIV/68081731:_____/17:00480406 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/17:00094662 RIV/00216305:26620/17:PU123018

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2017/7859289" target="_blank" >http://dx.doi.org/10.1155/2017/7859289</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2017/7859289" target="_blank" >10.1155/2017/7859289</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Popis výsledku v původním jazyce

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.

Název v anglickém jazyce

Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Popis výsledku anglicky

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. Thecitrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI)was then evaluated. The relaxivities (r(1),r(2)) and r(2)/r(1) ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T-2-contrast probe.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nanomaterials

ISSN

1687-4110

e-ISSN

—

Svazek periodika

2017

Číslo periodika v rámci svazku

FEB

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

000396144500001

EID výsledku v databázi Scopus

2-s2.0-85029210869