Improved assessment of arterial stiffness using corrected cardio-ankle vascular index (CAVI0) in overweight adolescents with white-coat and essential hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F17%3A00482732" target="_blank" >RIV/68081731:_____/17:00482732 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26220/17:PU125276

Výsledek na webu

<a href="http://dx.doi.org/10.1080/00365513.2017.1397286" target="_blank" >http://dx.doi.org/10.1080/00365513.2017.1397286</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00365513.2017.1397286" target="_blank" >10.1080/00365513.2017.1397286</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Improved assessment of arterial stiffness using corrected cardio-ankle vascular index (CAVI0) in overweight adolescents with white-coat and essential hypertension

Popis výsledku v původním jazyce

Arterial stiffness is a marker of vascular damage. Although adiposity increases cardiovascular risk, the relationship between paediatric overweight and arterial stiffness is unclear. The study aimed to evaluate the simultaneous effect of hypertension and overweight on arterial stiffness using cardio-ankle vascular index (CAVI) and related novel, theoretically blood pressure (BP)-independent, index CAVI(0). CAVI and CAVI(0) were measured in 140 adolescent boys (16.0 +/- 1.9 years) divided into age-matched groups: normal-weight normotensives, overweight normotensives, overweight white-coat hypertensives, and overweight essential hypertensives. Overweight normotensives had significantly lower CAVI and CAVI(0) compared to normal-weight normotensives (4.81 +/- 0.64 vs. 5.33 +/- 0.66, p<.01, 7.10 +/- 0.99 vs. 7.81 +/- 1.00, p<.01, respectively). CAVI and CAVI(0) in overweight essential hypertensives showed no significant difference compared to normal-weight normotensives and were significantly higher compared to overweight normotensives (5.32 +/- 0.77 vs. 4.81 +/- 0.64, p<.01, 7.77 +/- 1.19 vs. 7.10 +/- 0.99, p<.01, respectively). CAVI, but not CAVI0, was associated positively with diastolic pressure (0.022 mm Hg-1, p=.002) and negatively with pulse pressure (-0.022 mm Hg-1, p=.001), and it was significantly higher in overweight white-coat hypertensives compared to overweight normotensives (5.20 +/- 0.63 vs. 4.81 +/- 0.64, p<.05). The lowering effect of overweight on arterial stiffness indexed by CAVI and CAVI(0) in hypertensive adolescents seems to counterbalance the early arteriosclerotic effect of essential hypertension. The increase in CAVI, but not CAVI(0), in overweight white-coat hypertensives could be attributable to residual BP dependence of CAVI, which is not present in CAVI(0). Under certain conditions, CAVI(0) may offer a clinically relevant improved assessment of arterial stiffness superior to CAVI.

Název v anglickém jazyce

Improved assessment of arterial stiffness using corrected cardio-ankle vascular index (CAVI0) in overweight adolescents with white-coat and essential hypertension

Popis výsledku anglicky

Arterial stiffness is a marker of vascular damage. Although adiposity increases cardiovascular risk, the relationship between paediatric overweight and arterial stiffness is unclear. The study aimed to evaluate the simultaneous effect of hypertension and overweight on arterial stiffness using cardio-ankle vascular index (CAVI) and related novel, theoretically blood pressure (BP)-independent, index CAVI(0). CAVI and CAVI(0) were measured in 140 adolescent boys (16.0 +/- 1.9 years) divided into age-matched groups: normal-weight normotensives, overweight normotensives, overweight white-coat hypertensives, and overweight essential hypertensives. Overweight normotensives had significantly lower CAVI and CAVI(0) compared to normal-weight normotensives (4.81 +/- 0.64 vs. 5.33 +/- 0.66, p<.01, 7.10 +/- 0.99 vs. 7.81 +/- 1.00, p<.01, respectively). CAVI and CAVI(0) in overweight essential hypertensives showed no significant difference compared to normal-weight normotensives and were significantly higher compared to overweight normotensives (5.32 +/- 0.77 vs. 4.81 +/- 0.64, p<.01, 7.77 +/- 1.19 vs. 7.10 +/- 0.99, p<.01, respectively). CAVI, but not CAVI0, was associated positively with diastolic pressure (0.022 mm Hg-1, p=.002) and negatively with pulse pressure (-0.022 mm Hg-1, p=.001), and it was significantly higher in overweight white-coat hypertensives compared to overweight normotensives (5.20 +/- 0.63 vs. 4.81 +/- 0.64, p<.05). The lowering effect of overweight on arterial stiffness indexed by CAVI and CAVI(0) in hypertensive adolescents seems to counterbalance the early arteriosclerotic effect of essential hypertension. The increase in CAVI, but not CAVI(0), in overweight white-coat hypertensives could be attributable to residual BP dependence of CAVI, which is not present in CAVI(0). Under certain conditions, CAVI(0) may offer a clinically relevant improved assessment of arterial stiffness superior to CAVI.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scandinavian Journal of Clinical and Laboratory Investigation

ISSN

0036-5513

e-ISSN

—

Svazek periodika

77

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NO - Norské království

Počet stran výsledku

8

Strana od-do

665-672

Kód UT WoS článku

000416756100017

EID výsledku v databázi Scopus

2-s2.0-85033433032