The VED meter - A new tool to measure the ventricular conduction abnormalities in heart failure patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F17%3A00487040" target="_blank" >RIV/68081731:_____/17:00487040 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.cinc.org/archives/2017/" target="_blank" >http://www.cinc.org/archives/2017/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.22489/CinC.2017.377-059" target="_blank" >10.22489/CinC.2017.377-059</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The VED meter - A new tool to measure the ventricular conduction abnormalities in heart failure patients

Popis výsledku v původním jazyce

Heart failure patients with a left ventricular ejection fraction below or equal to 35%, QRS duration above 150 ms, and left bundle branch block (LBBB) are usually recommended for treatment with a cardiac resynchronization therapy (CRT) device. Yet, about one-third of these patients do not respond to CRT revealing the limit of the current patient management guidelines. For this reason, new methods for assessing the level of electrical ventricular delay (VED) are being explored. In this work, we present the VED Meter, autonomous software measuring the level of electrical activation delay from the standard body-surface electrocardiogram (ECG). The software delivers the VED parameter expressed in ms that reflects the electrical dyssynchrony between the right ventricle, septum and left ventricle lateral wall. We applied this software to the data from the MADIT-CRT trial to evaluate the VED values in three types of ventricular conduction disturbances: LBBB, right bundle branch block (RBBB), and intra-ventricular conduction disturbances (IVCD). We report that VED parameter has negative values for RBBB (delayed activation of the septum and the right ventricle) and positive for LBBB (delayed activation of the left ventricle lateral wall) which were significantly different at p<0.001.

Název v anglickém jazyce

The VED meter - A new tool to measure the ventricular conduction abnormalities in heart failure patients

Popis výsledku anglicky

Heart failure patients with a left ventricular ejection fraction below or equal to 35%, QRS duration above 150 ms, and left bundle branch block (LBBB) are usually recommended for treatment with a cardiac resynchronization therapy (CRT) device. Yet, about one-third of these patients do not respond to CRT revealing the limit of the current patient management guidelines. For this reason, new methods for assessing the level of electrical ventricular delay (VED) are being explored. In this work, we present the VED Meter, autonomous software measuring the level of electrical activation delay from the standard body-surface electrocardiogram (ECG). The software delivers the VED parameter expressed in ms that reflects the electrical dyssynchrony between the right ventricle, septum and left ventricle lateral wall. We applied this software to the data from the MADIT-CRT trial to evaluate the VED values in three types of ventricular conduction disturbances: LBBB, right bundle branch block (RBBB), and intra-ventricular conduction disturbances (IVCD). We report that VED parameter has negative values for RBBB (delayed activation of the septum and the right ventricle) and positive for LBBB (delayed activation of the left ventricle lateral wall) which were significantly different at p<0.001.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Computing in Cardiology 2017

ISBN

—

ISSN

2325-887X

e-ISSN

—

Počet stran výsledku

4

Strana od-do

1-4

Název nakladatele

Computing in Cardiology

Místo vydání

Rennes

Místo konání akce

Rennes

Datum konání akce

24. 9. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000450651100328