Focused ultrasound-induced blood-brain barrier opening: A comparative analysis of permeability quantification based on Ktrans and PS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081731%3A_____%2F25%3A00619015" target="_blank" >RIV/68081731:_____/25:00619015 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00143801 RIV/00216305:26220/26:0197784

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/mrm.30446" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/mrm.30446</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mrm.30446" target="_blank" >10.1002/mrm.30446</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Focused ultrasound-induced blood-brain barrier opening: A comparative analysis of permeability quantification based on Ktrans and PS

Popis výsledku v původním jazyce

Purpose: Focused ultrasound-induced blood-brain barrier (BBB) opening is a promising method for neurotherapeutic delivery. The standard for quantifying induced BBB permeability is the Ktrans parameter, which reflects both permeability and plasma flow. The influence of plasma flow can be eliminated by estimating the PS parameter. However, this parameter has been largely unexplored in this application. This study aims to compare permeability estimates based on Ktrans and PS in focused ultrasound-induced BBB opening experiments. Methods: We used the extended Tofts model (ETM) and the two-compartment exchange model (2CXM) to estimate Ktrans and PS parameters, respectively. Permeability estimates were compared using simulated concentration curves, simulated DCE-MRI data, and real datasets. We explored the influence of spatially-regularized model fitting on the results. Results: For opened BBB, Ktrans was minimally influenced by plasma flow under the tested conditions. However, fitting the ETM often introduced outliers in Ktrans estimates in regions with closed BBB. The 2CXM outperformed the ETM at high signal-to-noise ratios, but its higher complexity led to lower precision at low signal-to-noise ratios. Both these issues were successfully compensated by spatially-regularized model fitting. Conclusion: Both Ktrans and PS seem to be eligible options for the quantification of BBB opening, and the correct choice depends on the specifics of the acquired DCE-MRI data. Additionally, spatial regularization has demonstrated its importance in enhancing the accuracy and reproducibility of results for both models.

Název v anglickém jazyce

Focused ultrasound-induced blood-brain barrier opening: A comparative analysis of permeability quantification based on Ktrans and PS

Popis výsledku anglicky

Purpose: Focused ultrasound-induced blood-brain barrier (BBB) opening is a promising method for neurotherapeutic delivery. The standard for quantifying induced BBB permeability is the Ktrans parameter, which reflects both permeability and plasma flow. The influence of plasma flow can be eliminated by estimating the PS parameter. However, this parameter has been largely unexplored in this application. This study aims to compare permeability estimates based on Ktrans and PS in focused ultrasound-induced BBB opening experiments. Methods: We used the extended Tofts model (ETM) and the two-compartment exchange model (2CXM) to estimate Ktrans and PS parameters, respectively. Permeability estimates were compared using simulated concentration curves, simulated DCE-MRI data, and real datasets. We explored the influence of spatially-regularized model fitting on the results. Results: For opened BBB, Ktrans was minimally influenced by plasma flow under the tested conditions. However, fitting the ETM often introduced outliers in Ktrans estimates in regions with closed BBB. The 2CXM outperformed the ETM at high signal-to-noise ratios, but its higher complexity led to lower precision at low signal-to-noise ratios. Both these issues were successfully compensated by spatially-regularized model fitting. Conclusion: Both Ktrans and PS seem to be eligible options for the quantification of BBB opening, and the correct choice depends on the specifics of the acquired DCE-MRI data. Additionally, spatial regularization has demonstrated its importance in enhancing the accuracy and reproducibility of results for both models.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Magnetic Resonance in Medicine

ISSN

0740-3194

e-ISSN

1522-2594

Svazek periodika

93

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

2610-2622

Kód UT WoS článku

001423256400001

EID výsledku v databázi Scopus

2-s2.0-85219742503