Multiple cross-species transmission events of human adenoviruses (HAdV) during hominine evolution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F15%3A00447564" target="_blank" >RIV/68081766:_____/15:00447564 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/15:43873364

Výsledek na webu

<a href="http://dx.doi.org/10.1093/molbev/msv090" target="_blank" >http://dx.doi.org/10.1093/molbev/msv090</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/molbev/msv090" target="_blank" >10.1093/molbev/msv090</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multiple cross-species transmission events of human adenoviruses (HAdV) during hominine evolution

Popis výsledku v původním jazyce

Human adenoviruses (HAdV; species HAdV-A to -G) are highly prevalent in the human population, and represent an important cause of morbidity and, to a lesser extent, mortality. Recent studies have identified close relatives of these viruses in African great apes, suggesting that some HAdV may be of zoonotic origin. We analyzed more than 800 fecal samples from wild African great apes and humans to further investigate the evolutionary history and zoonotic potential of hominine HAdV. HAdV-B and -E were frequently detected in wild gorillas (55%) and chimpanzees (25%), respectively. Bayesian ancestral host reconstruction under discrete diffusion models supported a gorilla and chimpanzee origin for these viral species. Host switches were relatively rare alongHAdV evolution, with about ten events recorded in 4.5 My. Despite presumably rare direct contact between sympatric populations of the two species, transmission events from gorillas to chimpanzees were observed, suggesting that habitat an

Název v anglickém jazyce

Multiple cross-species transmission events of human adenoviruses (HAdV) during hominine evolution

Popis výsledku anglicky

Human adenoviruses (HAdV; species HAdV-A to -G) are highly prevalent in the human population, and represent an important cause of morbidity and, to a lesser extent, mortality. Recent studies have identified close relatives of these viruses in African great apes, suggesting that some HAdV may be of zoonotic origin. We analyzed more than 800 fecal samples from wild African great apes and humans to further investigate the evolutionary history and zoonotic potential of hominine HAdV. HAdV-B and -E were frequently detected in wild gorillas (55%) and chimpanzees (25%), respectively. Bayesian ancestral host reconstruction under discrete diffusion models supported a gorilla and chimpanzee origin for these viral species. Host switches were relatively rare alongHAdV evolution, with about ten events recorded in 4.5 My. Despite presumably rare direct contact between sympatric populations of the two species, transmission events from gorillas to chimpanzees were observed, suggesting that habitat an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/GA206%2F09%2F0927" target="_blank" >GA206/09/0927: Vliv zvýšeného kontaktu s člověkem na diverzitu a ekologii jednobuněčných parazitů afrických lidoopů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Biology and Evolution

ISSN

0737-4038

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

2072-2084

Kód UT WoS článku

000360586500013

EID výsledku v databázi Scopus

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