From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F16%3A00443676" target="_blank" >RIV/68081766:_____/16:00443676 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/brv.12183" target="_blank" >http://dx.doi.org/10.1111/brv.12183</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/brv.12183" target="_blank" >10.1111/brv.12183</a>

Jazyk výsledku

angličtina

Název v původním jazyce

From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology

Popis výsledku v původním jazyce

African annual fishes from the genus Nothobranchius are small teleosts that inhabit temporary water bodies subject to annual desiccation due to the alternation of the monsoon seasons. In the laboratory, adults of different Nothobranchius species and populations live between three and 18 months and, notably, there is a negative correlation between the captive lifespan of a species and the aridity of their habitat. Their short lifespan is coupled to rapid age-dependent functional decline and expression of cellular and molecular changes comparable to those observed in other vertebrates, including humans. The recent development of transgenesis in this species makes it possible to insert specific constructs into their genome, and the establishment of transgenic lines is facilitated by their very rapid generation time, which can be as short as one month. This makes Nothobranchius species particularly suited for investigating biological and molecular aspects of ageing and ageing-associated dysfunctions. At the same time, they also represent a unique model taxon to investigate the evolution of life-history adaptations and their genetic architecture. We review their natural history, including phylogenetic relationships, distribution in relation to habitat conditions and natural selection for differential longevity, population structure and demography, and life cycle with emphasis on diapause that may occur at three stages during embryonic development.

Název v anglickém jazyce

From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology

Popis výsledku anglicky

African annual fishes from the genus Nothobranchius are small teleosts that inhabit temporary water bodies subject to annual desiccation due to the alternation of the monsoon seasons. In the laboratory, adults of different Nothobranchius species and populations live between three and 18 months and, notably, there is a negative correlation between the captive lifespan of a species and the aridity of their habitat. Their short lifespan is coupled to rapid age-dependent functional decline and expression of cellular and molecular changes comparable to those observed in other vertebrates, including humans. The recent development of transgenesis in this species makes it possible to insert specific constructs into their genome, and the establishment of transgenic lines is facilitated by their very rapid generation time, which can be as short as one month. This makes Nothobranchius species particularly suited for investigating biological and molecular aspects of ageing and ageing-associated dysfunctions. At the same time, they also represent a unique model taxon to investigate the evolution of life-history adaptations and their genetic architecture. We review their natural history, including phylogenetic relationships, distribution in relation to habitat conditions and natural selection for differential longevity, population structure and demography, and life cycle with emphasis on diapause that may occur at three stages during embryonic development.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP506%2F11%2F0112" target="_blank" >GAP506/11/0112: Evoluce rychlé senescence a její vliv na ostatní složky životní strategie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biological Reviews

ISSN

1464-7931

e-ISSN

—

Svazek periodika

91

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

23

Strana od-do

511-533

Kód UT WoS článku

000373906400014

EID výsledku v databázi Scopus

2-s2.0-84928753640