100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F17%3A00475331" target="_blank" >RIV/68081766:_____/17:00475331 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12864-017-3839-7" target="_blank" >http://dx.doi.org/10.1186/s12864-017-3839-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12864-017-3839-7" target="_blank" >10.1186/s12864-017-3839-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

Popis výsledku v původním jazyce

Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates’ host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.nResults: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.nConclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.

Název v anglickém jazyce

100 million years of multigene family evolution: origin and evolution of the avian MHC class IIB

Popis výsledku anglicky

Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates’ host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds.nResults: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event prior to the radiation of all extant birds >100 million years ago, and document the role of concerted evolution in eroding the footprints of the avian MHCIIB duplication history.nConclusions: Our results suggest that eroded footprints of gene duplication histories may mimic birth-death evolution and that in the avian MHC the presence of the two lineages may have been masked by elevated rates of concerted evolution in several taxa. Through the presence of a range of intermediate evolutionary stages along the homogenizing process of concerted evolution, the avian MHCIIB provides a remarkable illustration of the erosion of multigene family duplication history.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

<a href="/cs/project/GAP505%2F10%2F1871" target="_blank" >GAP505/10/1871: Toll-like receptory u pěvců: popis, polymorfismus a evoluční důsledky alelické variability</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Genomics

ISSN

1471-2164

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

460

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

1-9

Kód UT WoS článku

000413749900001

EID výsledku v databázi Scopus

2-s2.0-85020646288