Neurotropic tick-borne flavivirus in Alpine chamois (Rupicapra rupicapra rupicapra), Austria, 2017, Italy, 2023

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F25%3A00605595" target="_blank" >RIV/68081766:_____/25:00605595 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/1999-4915/17/1/122" target="_blank" >https://www.mdpi.com/1999-4915/17/1/122</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/v17010122" target="_blank" >10.3390/v17010122</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neurotropic tick-borne flavivirus in Alpine chamois (Rupicapra rupicapra rupicapra), Austria, 2017, Italy, 2023

Popis výsledku v původním jazyce

The European subtype of tick-borne encephalitis virus (TBEV-Eur, species Orthoflavivirus encephalitidis, family Flaviviridae) was the only tick-borne flavivirus present in central Europe known to cause neurologic disease in humans and several animal species. Here, we report a tick-borne flavivirus isolated from Alpine chamois (Rupicapra rupicapra rupicapra) with encephalitis and attached ticks, present over a wide area in the Alps. Cases were detected in 2017 in Salzburg, Austria, and 2023 in Lombardy and Piedmont, Italy. The virus strains exhibit 94.8-97.3% nucleotide identities to each other and are more closely related to Louping ill viruses (LIV, Orthoflavivirus loupingi, 90-92% identities) than to TBEV-Eur (less than 88%). The chamois-derived virus strains, tentatively termed 'Alpine chamois encephalitis virus', form a well-supported independent genetic clade with Spanish goat encephalitis virus, clearly separated from other LIV. This supports its designation as a new virus subtype with the proposed shared taxonomic name 'Spanish goat and Alpine chamois encephalitis virus subtype' within the species Orthoflavivirus loupingi. The zoonotic potential of this newly identified virus subtype as well as its host range in other animal species including farm animals needs to be further investigated.

Název v anglickém jazyce

Neurotropic tick-borne flavivirus in Alpine chamois (Rupicapra rupicapra rupicapra), Austria, 2017, Italy, 2023

Popis výsledku anglicky

The European subtype of tick-borne encephalitis virus (TBEV-Eur, species Orthoflavivirus encephalitidis, family Flaviviridae) was the only tick-borne flavivirus present in central Europe known to cause neurologic disease in humans and several animal species. Here, we report a tick-borne flavivirus isolated from Alpine chamois (Rupicapra rupicapra rupicapra) with encephalitis and attached ticks, present over a wide area in the Alps. Cases were detected in 2017 in Salzburg, Austria, and 2023 in Lombardy and Piedmont, Italy. The virus strains exhibit 94.8-97.3% nucleotide identities to each other and are more closely related to Louping ill viruses (LIV, Orthoflavivirus loupingi, 90-92% identities) than to TBEV-Eur (less than 88%). The chamois-derived virus strains, tentatively termed 'Alpine chamois encephalitis virus', form a well-supported independent genetic clade with Spanish goat encephalitis virus, clearly separated from other LIV. This supports its designation as a new virus subtype with the proposed shared taxonomic name 'Spanish goat and Alpine chamois encephalitis virus subtype' within the species Orthoflavivirus loupingi. The zoonotic potential of this newly identified virus subtype as well as its host range in other animal species including farm animals needs to be further investigated.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10607 - Virology

Projekt

<a href="/cs/project/NU21-05-00143" target="_blank" >NU21-05-00143: Skryté zoonózy - odhalování nových patogenů z volné přírody</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Viruses

ISSN

1999-4915

e-ISSN

1999-4915

Svazek periodika

17

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

122

Kód UT WoS článku

001404522600001

EID výsledku v databázi Scopus

2-s2.0-85216076653