Comparative genomic analysis of co-occurring hybrid zones of house mouse parasites Pneumocystis murina and Syphacia obvelata using genome polarisation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081766%3A_____%2F25%3A00640470" target="_blank" >RIV/68081766:_____/25:00640470 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/25:00142575

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/mec.70044" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/mec.70044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/mec.70044" target="_blank" >10.1111/mec.70044</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparative genomic analysis of co-occurring hybrid zones of house mouse parasites Pneumocystis murina and Syphacia obvelata using genome polarisation

Popis výsledku v původním jazyce

Parasites are expected to hybridise in similar ways to free-living organisms, although this may be modified by their reduced genome architecture. Recombinant strains and taxa of hybrid origin can be studied in nature where hosts come into secondary contact. Here we apply genome-wide analysis to parasites from a contact previously characterised for many individuals using classical markers. The host contact is the European house mouse hybrid zone, the parasites are lung fungus Pneumocystis and gut pinworm Syphacia. The genomic (many loci) and classical (many-individual) results are broadly consistent in scale and centring of transitions across the host hybrid zone. Whole mitogenome comparisons confirm earlier suggestions that parasite divergence is low compared to their hosts, perhaps due to reduced-genome stabilising selection. In the recombining genome, we are able to show blocks of the parasite genome of alternating host origin, including one Pneumocystis strain which appears to be an F3+ cross and one recombinant Syphacia strain found over multiple localities. Functional analyses of introgressing genes show enrichment for genes likely important for parasitic lifestyle. Our work confirms that evolutionary models of hybridisation apply equally to hosts and their parasites.

Název v anglickém jazyce

Comparative genomic analysis of co-occurring hybrid zones of house mouse parasites Pneumocystis murina and Syphacia obvelata using genome polarisation

Popis výsledku anglicky

Parasites are expected to hybridise in similar ways to free-living organisms, although this may be modified by their reduced genome architecture. Recombinant strains and taxa of hybrid origin can be studied in nature where hosts come into secondary contact. Here we apply genome-wide analysis to parasites from a contact previously characterised for many individuals using classical markers. The host contact is the European house mouse hybrid zone, the parasites are lung fungus Pneumocystis and gut pinworm Syphacia. The genomic (many loci) and classical (many-individual) results are broadly consistent in scale and centring of transitions across the host hybrid zone. Whole mitogenome comparisons confirm earlier suggestions that parasite divergence is low compared to their hosts, perhaps due to reduced-genome stabilising selection. In the recombining genome, we are able to show blocks of the parasite genome of alternating host origin, including one Pneumocystis strain which appears to be an F3+ cross and one recombinant Syphacia strain found over multiple localities. Functional analyses of introgressing genes show enrichment for genes likely important for parasitic lifestyle. Our work confirms that evolutionary models of hybridisation apply equally to hosts and their parasites.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Ecology

ISSN

0962-1083

e-ISSN

1365-294X

Svazek periodika

34

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

23

Strana od-do

e70044

Kód UT WoS článku

001592304500001

EID výsledku v databázi Scopus

2-s2.0-105018761153