The Developing Mouse Dentition - a new tool for apoptosis study.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F03%3A19043003" target="_blank" >RIV/68378041:_____/03:19043003 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Developing Mouse Dentition - a new tool for apoptosis study.

Popis výsledku v původním jazyce

We proposed a hypothesis to explain the stimulation of apoptosis in the dental epithelium by integrating two concepts:(1) The regulation of epithelial bidding by positional information generated from interactions between growth-activating and growth-inhibiting signals, and (2) apoptosis stimulation by the failure of death-suppressing signals. During the budding of the dental epithelium, local excess in growth inhibitors (e.g.,Bmps)might lead to the epithelial cells' failure to receive adequate growth-activating (apoptosis-suppressing) signals. The resulting signal imbalance leads to cell suicide by apoptosis. Understanding of apoptosis regulation in the vestigial tooth primordia can help to elucidate the mechanism of their suppression during evolutionand to identify factors essential for tooth survival. The latter knowledge will be important for developing a technology of tooth engineering.

Název v anglickém jazyce

The Developing Mouse Dentition - a new tool for apoptosis study.

Popis výsledku anglicky

We proposed a hypothesis to explain the stimulation of apoptosis in the dental epithelium by integrating two concepts:(1) The regulation of epithelial bidding by positional information generated from interactions between growth-activating and growth-inhibiting signals, and (2) apoptosis stimulation by the failure of death-suppressing signals. During the budding of the dental epithelium, local excess in growth inhibitors (e.g.,Bmps)might lead to the epithelial cells' failure to receive adequate growth-activating (apoptosis-suppressing) signals. The resulting signal imbalance leads to cell suicide by apoptosis. Understanding of apoptosis regulation in the vestigial tooth primordia can help to elucidate the mechanism of their suppression during evolutionand to identify factors essential for tooth survival. The latter knowledge will be important for developing a technology of tooth engineering.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA304%2F02%2F0448" target="_blank" >GA304/02/0448: Pučení epitelu jako mechanismus vývoje dentice</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of the New York Academy of Science

ISSN

0077-8923

e-ISSN

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Svazek periodika

1010

Číslo periodika v rámci svazku

N/A

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

453-466

Kód UT WoS článku

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EID výsledku v databázi Scopus

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