Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F10%3A00345709" target="_blank" >RIV/68378041:_____/10:00345709 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

Popis výsledku v původním jazyce

Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase reactivates plasticity. In this article has been measured the changes in the CSPGs that occur during the critical period in rats and mice. The molecular event that triggers PNN formation has been identified, showing that the PNN component cartilage link protein Crtl1 (Hapln1) is up-regulated as the structures form. In keeping with the hypothesis that PNN maturation down-regulates plasticity, we found that adult plasticity in the visual and somatosensory systems of mice lacking Crtl1 was strongly enhanced. Overall, our findings demonstrate that the formation of PNNs triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS and suggest that modification of PNNs is how CSPGs reactivate plasticity.

Název v anglickém jazyce

Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

Popis výsledku anglicky

Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase reactivates plasticity. In this article has been measured the changes in the CSPGs that occur during the critical period in rats and mice. The molecular event that triggers PNN formation has been identified, showing that the PNN component cartilage link protein Crtl1 (Hapln1) is up-regulated as the structures form. In keeping with the hypothesis that PNN maturation down-regulates plasticity, we found that adult plasticity in the visual and somatosensory systems of mice lacking Crtl1 was strongly enhanced. Overall, our findings demonstrate that the formation of PNNs triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS and suggest that modification of PNNs is how CSPGs reactivate plasticity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain

ISSN

0006-8950

e-ISSN

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Svazek periodika

133

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

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Kód UT WoS článku

000280982700015

EID výsledku v databázi Scopus

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