Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease

Popis výsledku v původním jazyce

We monitored changes in the astroglia morphology throughout the age-dependent progression of AD, in the hippocampus of a triple transgenic mouse model of AD (3xTg-AD) that mimics the temporal progression of the human disease. We found astrocytic atrophyin both the dentate gyrus and hippocampal CA1 field from middle age (12 months onwards). However, astroglial atrophy appears as a generalised process, astrocytes that surround neuritic plaques are clearly hypertrophic which suggest differential effects of AD on astroglial populations depending on their association with plaques which account for the progressive disruption of connectivity in neural networks and neurotransmitters imbalance which underlie cognitive impairments observed in AD.

Název v anglickém jazyce

Concomitant Astroglial Atrophy and Astrogliosis in a Triple Transgenic Animal Model of Alzheimer's Disease

Popis výsledku anglicky

We monitored changes in the astroglia morphology throughout the age-dependent progression of AD, in the hippocampus of a triple transgenic mouse model of AD (3xTg-AD) that mimics the temporal progression of the human disease. We found astrocytic atrophyin both the dentate gyrus and hippocampal CA1 field from middle age (12 months onwards). However, astroglial atrophy appears as a generalised process, astrocytes that surround neuritic plaques are clearly hypertrophic which suggest differential effects of AD on astroglial populations depending on their association with plaques which account for the progressive disruption of connectivity in neural networks and neurotransmitters imbalance which underlie cognitive impairments observed in AD.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Glia

ISSN

0894-1491

e-ISSN

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Svazek periodika

58

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000276678500008

EID výsledku v databázi Scopus

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