Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F11%3A00353964" target="_blank" >RIV/68378041:_____/11:00353964 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure

Popis výsledku v původním jazyce

This mini-review presents the current stage of development of the Metasystems Metafer MNScore system for automated image analysis scoring of micronuclei (MN) in human lymphocytes. A new field for application of this method was opened in 2009, when it wasused in a biomonitoring study, assessing the effect of exposure to carcinogenic PAHs in ambient air on the frequency of MN in a group of policemen from Prague. The data from further studies are also presented, in which the above mentioned analysis system was used to evaluate the impact of air pollution on MN in bus drivers, asthmatic children, office and laboratory workers. It is concluded that the automated image analysis is a promising tool for improving risk assessment of human populations exposed to environmental or occupational mutagens.

Název v anglickém jazyce

Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure

Popis výsledku anglicky

This mini-review presents the current stage of development of the Metasystems Metafer MNScore system for automated image analysis scoring of micronuclei (MN) in human lymphocytes. A new field for application of this method was opened in 2009, when it wasused in a biomonitoring study, assessing the effect of exposure to carcinogenic PAHs in ambient air on the frequency of MN in a group of policemen from Prague. The data from further studies are also presented, in which the above mentioned analysis system was used to evaluate the impact of air pollution on MN in bus drivers, asthmatic children, office and laboratory workers. It is concluded that the automated image analysis is a promising tool for improving risk assessment of human populations exposed to environmental or occupational mutagens.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mutagenesis

ISSN

0267-8357

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000285627700025

EID výsledku v databázi Scopus

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