Age-related changes in calbindin and calretinin immunoreactivity in the central auditory system of the rat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F12%3A00379814" target="_blank" >RIV/68378041:_____/12:00379814 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.exger.2012.04.003" target="_blank" >http://dx.doi.org/10.1016/j.exger.2012.04.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.exger.2012.04.003" target="_blank" >10.1016/j.exger.2012.04.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Age-related changes in calbindin and calretinin immunoreactivity in the central auditory system of the rat

Popis výsledku v původním jazyce

Age-related changes in the expression of intracellular calcium buffers calbindin and calretinin were evaluated in the central auditory structures in two rat strains, the slowly aging Long-Evans and the fast aging Fischer 344 rats. Our results demonstrated significant age-related decrease in the number and volumes of immunoreactive neurons and decreased protein levels similarly in both rat strains regardless their differently preserved inner ear function. The decline in calbindin protein levels and number of calbindin expressing neurons was more pronounced in comparison with the changes in calretinin immunoreactivity. The observed age-related changes in the calbindin- and calretinin-expressing systems may contribute significantly to the deterioration ofhearing function known as central presbycusis.

Název v anglickém jazyce

Age-related changes in calbindin and calretinin immunoreactivity in the central auditory system of the rat

Popis výsledku anglicky

Age-related changes in the expression of intracellular calcium buffers calbindin and calretinin were evaluated in the central auditory structures in two rat strains, the slowly aging Long-Evans and the fast aging Fischer 344 rats. Our results demonstrated significant age-related decrease in the number and volumes of immunoreactive neurons and decreased protein levels similarly in both rat strains regardless their differently preserved inner ear function. The decline in calbindin protein levels and number of calbindin expressing neurons was more pronounced in comparison with the changes in calretinin immunoreactivity. The observed age-related changes in the calbindin- and calretinin-expressing systems may contribute significantly to the deterioration ofhearing function known as central presbycusis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental Gerontology

ISSN

0531-5565

e-ISSN

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Svazek periodika

47

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

497-506

Kód UT WoS článku

000304813200003

EID výsledku v databázi Scopus

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