Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F14%3A00395393" target="_blank" >RIV/68378041:_____/14:00395393 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ijc.28383" target="_blank" >http://dx.doi.org/10.1002/ijc.28383</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ijc.28383" target="_blank" >10.1002/ijc.28383</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk

Popis výsledku v původním jazyce

Polymorphisms in MMR (mismatch repair) or other DNA repair gene variants may modify the association between recreational physical activity (RPA) and breast cancer incidence. In this study, the individual and joint effects of variants in three MMR pathwaygenes (MSH3, MLH1 and MSH2) on breast cancer occurence using resources from the Long Island Breast Cancer Study Project were investigated. Additionally, the interactions between RPA and genetic polymorphisms in MMR, BER (base excision repair) and NER (nucleotide excision repair) pathways were characterized. Obtained data show that women with minor alleles in both MSH2 and MLH1 could be at increased breast cancer risk. RPA may be modified by genes in the DNA repair pathway, and merit further investigation.

Název v anglickém jazyce

Polymorphisms in DNA repair genes, recreational physical activity and breast cancer risk

Popis výsledku anglicky

Polymorphisms in MMR (mismatch repair) or other DNA repair gene variants may modify the association between recreational physical activity (RPA) and breast cancer incidence. In this study, the individual and joint effects of variants in three MMR pathwaygenes (MSH3, MLH1 and MSH2) on breast cancer occurence using resources from the Long Island Breast Cancer Study Project were investigated. Additionally, the interactions between RPA and genetic polymorphisms in MMR, BER (base excision repair) and NER (nucleotide excision repair) pathways were characterized. Obtained data show that women with minor alleles in both MSH2 and MLH1 could be at increased breast cancer risk. RPA may be modified by genes in the DNA repair pathway, and merit further investigation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cancer

ISSN

0020-7136

e-ISSN

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Svazek periodika

134

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

654-663

Kód UT WoS článku

000326880600016

EID výsledku v databázi Scopus

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