Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00438519" target="_blank" >RIV/68378041:_____/15:00438519 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1177/0022034514556707" target="_blank" >http://dx.doi.org/10.1177/0022034514556707</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0022034514556707" target="_blank" >10.1177/0022034514556707</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium

Popis výsledku v původním jazyce

Nuclear factor kappa B (NF-?B) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-?B signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-?B signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKK?, an essential component of the NF-?B pathway, under keratin 5 promoter (K5-Ikk?). K5-Ikk? mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikk? mice. The supernumerary incisors in K5-Ikk? mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-?B activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.

Název v anglickém jazyce

Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium

Popis výsledku anglicky

Nuclear factor kappa B (NF-?B) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-?B signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-?B signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKK?, an essential component of the NF-?B pathway, under keratin 5 promoter (K5-Ikk?). K5-Ikk? mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikk? mice. The supernumerary incisors in K5-Ikk? mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-?B activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GB14-37368G" target="_blank" >GB14-37368G: Centrum orofaciálního vývoje a regenerace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Dental Research

ISSN

0022-0345

e-ISSN

—

Svazek periodika

94

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

121-128

Kód UT WoS článku

000346506200016

EID výsledku v databázi Scopus

2-s2.0-84919464755