Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00452269" target="_blank" >RIV/68378041:_____/15:00452269 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064190:_____/15:#0001058 RIV/00216208:11110/15:10295096

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12885-015-1327-5" target="_blank" >http://dx.doi.org/10.1186/s12885-015-1327-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12885-015-1327-5" target="_blank" >10.1186/s12885-015-1327-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

Popis výsledku v původním jazyce

Background: Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineatingpatients with polyps and benign adenomas from normal and cancer patient groups. Methods: The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. Three miRNAs (miR-34a, miR-150, and miR-923) were further examined in a validation cohort of 97 subjects divided into the same five groups, and in an independent public dataset of 40 CRC samples and paired normal tissues. Results: High levels of circulating miR-34a and low miR-150 levels distinguished groups of patients with polyps from those with advanced cancer (AUC = 0.904), and low circulating miR-150 levels separated patients with adenomas from those with advanced cancer (AUC = 0.875). In ad

Název v anglickém jazyce

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

Popis výsledku anglicky

Background: Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineatingpatients with polyps and benign adenomas from normal and cancer patient groups. Methods: The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. Three miRNAs (miR-34a, miR-150, and miR-923) were further examined in a validation cohort of 97 subjects divided into the same five groups, and in an independent public dataset of 40 CRC samples and paired normal tissues. Results: High levels of circulating miR-34a and low miR-150 levels distinguished groups of patients with polyps from those with advanced cancer (AUC = 0.904), and low circulating miR-150 levels separated patients with adenomas from those with advanced cancer (AUC = 0.875). In ad

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bmc Cancer

ISSN

1471-2407

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

apr 30

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

2-13

Kód UT WoS článku

000353771200002

EID výsledku v databázi Scopus

2-s2.0-84928819020