The age dependence of T2 relaxation times of N-acetyl aspartate, creatine and choline in the human brain at 3 and 4T

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00459635" target="_blank" >RIV/68378041:_____/16:00459635 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/16:10323702 RIV/00023001:_____/16:00059822 RIV/00216208:11110/16:10323702 RIV/00159816:_____/16:00068473

Výsledek na webu

<a href="http://dx.doi.org/10.1002/nbm.3456" target="_blank" >http://dx.doi.org/10.1002/nbm.3456</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/nbm.3456" target="_blank" >10.1002/nbm.3456</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The age dependence of T2 relaxation times of N-acetyl aspartate, creatine and choline in the human brain at 3 and 4T

Popis výsledku v původním jazyce

Knowledge of the T-2 age dependence is of importance for MRS clinical studies involving subject groups with a wide age range. A number of studies have focused on the age dependence of T-2 values in the human brain, with rather conflicting results. The aim of this study was to analyze the age dependence of T-2 values of N-acetyl aspartate (NAA), creatine (Cr) and choline (Cho) in the human brain using data acquired at 3T and 4T and to assess the influence of the macromolecule (MM) baseline handling on the obtained results. Two distinct groups of young and elderly controls have been measured at 3T (T-E = 30-540 ms, 9 young and 11 elderly subjects) and 4T (T-E = 10-180 ms, 18 young and 14 elderly subjects) using single-voxel spectroscopy. In addition, MM spectra were measured from two subjects using the inversion-recovery technique at 4T. All spectra were processed with LCModel using basis sets with different MM signals (measured or simulated) and also with MM signals included for a different T-E range. Individual estimated T-2 values were statistically analyzed using the R programming language for the age dependence of T-2 values as well as the influence of the MM baseline handling. A significant decrease of T-2 values of NAA and Cr in elderly subjects compared with young subjects was confirmed. The same trend was observed for Cho. Significantly higher T-2 values calculated using the measured MM baseline for all studied metabolites at 4T were observed for both young and elderly subjects. To conclude, while the handling of MM and lipid signals may have a significant effect on estimated T-2 values, we confirmed the age dependence of T-2 values of NAA and Cr and the same trend for Cho in the human brain.

Název v anglickém jazyce

The age dependence of T2 relaxation times of N-acetyl aspartate, creatine and choline in the human brain at 3 and 4T

Popis výsledku anglicky

Knowledge of the T-2 age dependence is of importance for MRS clinical studies involving subject groups with a wide age range. A number of studies have focused on the age dependence of T-2 values in the human brain, with rather conflicting results. The aim of this study was to analyze the age dependence of T-2 values of N-acetyl aspartate (NAA), creatine (Cr) and choline (Cho) in the human brain using data acquired at 3T and 4T and to assess the influence of the macromolecule (MM) baseline handling on the obtained results. Two distinct groups of young and elderly controls have been measured at 3T (T-E = 30-540 ms, 9 young and 11 elderly subjects) and 4T (T-E = 10-180 ms, 18 young and 14 elderly subjects) using single-voxel spectroscopy. In addition, MM spectra were measured from two subjects using the inversion-recovery technique at 4T. All spectra were processed with LCModel using basis sets with different MM signals (measured or simulated) and also with MM signals included for a different T-E range. Individual estimated T-2 values were statistically analyzed using the R programming language for the age dependence of T-2 values as well as the influence of the MM baseline handling. A significant decrease of T-2 values of NAA and Cr in elderly subjects compared with young subjects was confirmed. The same trend was observed for Cho. Significantly higher T-2 values calculated using the measured MM baseline for all studied metabolites at 4T were observed for both young and elderly subjects. To conclude, while the handling of MM and lipid signals may have a significant effect on estimated T-2 values, we confirmed the age dependence of T-2 values of NAA and Cr and the same trend for Cho in the human brain.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nmr in Biomedicine

ISSN

0952-3480

e-ISSN

—

Svazek periodika

29

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

284-292

Kód UT WoS článku

000371426000009

EID výsledku v databázi Scopus

2-s2.0-84954185122