Transmembrane voltage: Potential to induce lateral microdomains.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00459657" target="_blank" >RIV/68378041:_____/16:00459657 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bbalip.2016.02.012" target="_blank" >http://dx.doi.org/10.1016/j.bbalip.2016.02.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbalip.2016.02.012" target="_blank" >10.1016/j.bbalip.2016.02.012</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Transmembrane voltage: Potential to induce lateral microdomains.

Popis výsledku v původním jazyce

Lateral lipid microdomains of specific composition, structure and biological functions are established as a result of simultaneous action of several competing mechanisms which contribute to membrane organization. Various lines of evidence support the conclusion that among those mechanisms, the membrane potential plays significant and to some extent unique role. Here we summarize clear differences in the microdomain structure between polarized and depolarized membranes as revealed by fluorescence microscopy and fluorescence spectroscopy experiments in the context of earlier findings reporting decreased susceptibility to detergents and sensitivity to antibiotics or antimycotics treatment of the depolarized plasma membrane. A model is discussed, in which membrane potential-driven re-organization of the microdomain structure contributes to maintaining membrane integrity during response to stress, pathogen attack and other challenges involving partial plasma membrane depolarization.

Název v anglickém jazyce

Transmembrane voltage: Potential to induce lateral microdomains.

Popis výsledku anglicky

Lateral lipid microdomains of specific composition, structure and biological functions are established as a result of simultaneous action of several competing mechanisms which contribute to membrane organization. Various lines of evidence support the conclusion that among those mechanisms, the membrane potential plays significant and to some extent unique role. Here we summarize clear differences in the microdomain structure between polarized and depolarized membranes as revealed by fluorescence microscopy and fluorescence spectroscopy experiments in the context of earlier findings reporting decreased susceptibility to detergents and sensitivity to antibiotics or antimycotics treatment of the depolarized plasma membrane. A model is discussed, in which membrane potential-driven re-organization of the microdomain structure contributes to maintaining membrane integrity during response to stress, pathogen attack and other challenges involving partial plasma membrane depolarization.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA15-10641S" target="_blank" >GA15-10641S: Specifické mikrodomény plasmatické membrány v regulaci stárnutí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids

ISSN

1388-1981

e-ISSN

—

Svazek periodika

1861

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

806-811

Kód UT WoS článku

000385785500006

EID výsledku v databázi Scopus

2-s2.0-84959247759