Multipotency and therapeutic potential of NG2 cells.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00476751" target="_blank" >RIV/68378041:_____/17:00476751 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bcp.2017.05.008" target="_blank" >http://dx.doi.org/10.1016/j.bcp.2017.05.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bcp.2017.05.008" target="_blank" >10.1016/j.bcp.2017.05.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multipotency and therapeutic potential of NG2 cells.

Popis výsledku v původním jazyce

NG2 cells represent one of the most proliferative glial cell populations in the intact mammalian central nervous system (CNS). They are well-known for their ability to renew themselves or to generate new oligodendrocytes during development as well as in adulthood, therefore also being termed oligodendrocyte progenitor cells. Following CNS injuries, such as demyelination, trauma or ischemia, the proliferative capacity of NG2 cells rapidly increases and moreover, their differentiation potential broadens, as documented by numerous reports also describing their differentiation into astrocytes or even neurons. Here, we summarize the current knowledge about NG2 cells proliferation, their fate plasticity during embryogenesis as well as in postnatal CNS under physiological and pathological conditions, with the main emphasis on the role of various signaling molecules, growth factors, hormones or even neurotransmitters on the fate potential of NG2 cells. (c) 2017 Elsevier Inc. All rights reserved.

Název v anglickém jazyce

Multipotency and therapeutic potential of NG2 cells.

Popis výsledku anglicky

NG2 cells represent one of the most proliferative glial cell populations in the intact mammalian central nervous system (CNS). They are well-known for their ability to renew themselves or to generate new oligodendrocytes during development as well as in adulthood, therefore also being termed oligodendrocyte progenitor cells. Following CNS injuries, such as demyelination, trauma or ischemia, the proliferative capacity of NG2 cells rapidly increases and moreover, their differentiation potential broadens, as documented by numerous reports also describing their differentiation into astrocytes or even neurons. Here, we summarize the current knowledge about NG2 cells proliferation, their fate plasticity during embryogenesis as well as in postnatal CNS under physiological and pathological conditions, with the main emphasis on the role of various signaling molecules, growth factors, hormones or even neurotransmitters on the fate potential of NG2 cells. (c) 2017 Elsevier Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/GA17-04034S" target="_blank" >GA17-04034S: Klíčové signální dráhy regulující proliferaci a diferenciaci NG2 gliových buněk v poškozené nervové tkáni mozku</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochemical Pharmacology

ISSN

0006-2952

e-ISSN

—

Svazek periodika

141

Číslo periodika v rámci svazku

SI

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

42-55

Kód UT WoS článku

000411656600004

EID výsledku v databázi Scopus

2-s2.0-85019637465