Study of Synergistic Effect of Mesenchymal Stem Cells and Immunosuppressive Drugs on an Inflammatory Response in an In Vitro Model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00491806" target="_blank" >RIV/68378041:_____/17:00491806 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of Synergistic Effect of Mesenchymal Stem Cells and Immunosuppressive Drugs on an Inflammatory Response in an In Vitro Model

Popis výsledku v původním jazyce

Mesenchymal stem cells (MSCs) in combination with immunosuppressive drugs are beneficial in the treatment of inflammatory diseases or transplantation reaction. We tested immunosuppressive drugs with different mechanism of action: cyclosporine A, mycophenolate mofetil and rapamycin in combination with MSCs. By flow cytometry we determined T regulatory cells (CD4+Foxp3+) and Th 17 cells (CD4+RORt+) proportion and the production of IL-17 was measured by ELISA. This study demonstrated that MSCs in combination with different immunosuppressive agents at low concentration have distinct effect on the Treg/Th17 balance.

Název v anglickém jazyce

Study of Synergistic Effect of Mesenchymal Stem Cells and Immunosuppressive Drugs on an Inflammatory Response in an In Vitro Model

Popis výsledku anglicky

Mesenchymal stem cells (MSCs) in combination with immunosuppressive drugs are beneficial in the treatment of inflammatory diseases or transplantation reaction. We tested immunosuppressive drugs with different mechanism of action: cyclosporine A, mycophenolate mofetil and rapamycin in combination with MSCs. By flow cytometry we determined T regulatory cells (CD4+Foxp3+) and Th 17 cells (CD4+RORt+) proportion and the production of IL-17 was measured by ELISA. This study demonstrated that MSCs in combination with different immunosuppressive agents at low concentration have distinct effect on the Treg/Th17 balance.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1309" target="_blank" >LO1309: Buněčná terapie a tkáňové náhrady</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanomaterials in Biomedical research

ISBN

978-80-906655-5-2

Počet stran výsledku

5

Strana od-do

124-128

Počet stran knihy

140

Název nakladatele

Proxima Tisk, s.r.o.

Místo vydání

Praha 3

Kód UT WoS kapitoly

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