Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat

Kód výsledku v IS VaVaI

RIV/68378041:_____/18:00493479 - isvavai.cz

Nalezeny alternativní kódy

RIV/71226401:_____/18:N0100112

Výsledek na webu

http://dx.doi.org/10.1155/2018/5903720

DOI - Digital Object Identifier

10.1155/2018/5903720

Jazyk výsledku

angličtina

Název v původním jazyce

Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat

Popis výsledku v původním jazyce

It is well known that auditory experience during early development shapes response properties of auditory cortex (AC) neurons, influencing, for example, tonotopical arrangement, response thresholds and strength, or frequency selectivity. Here, we show that rearing rat pups in a complex acoustically enriched environment leads to an increased reliability of responses of AC neurons, affecting both the rate and the temporal codes. For a repetitive stimulus, the neurons exhibit a lower spike count variance, indicating a more stable rate coding. At the level of individual spikes, the discharge patterns of individual neurons show a higher degree of similarity across stimulus repetitions. Furthermore, the neurons follow more precisely the temporal course of the stimulus, as manifested by improved phase-locking to temporally modulated sounds. The changes are persistent and present up to adulthood. The results document that besides basic alterations of receptive fields presented in our previous study, the acoustic environment during the critical period of postnatal development also leads to a decreased stochasticity and a higher reproducibility of neuronal spiking patterns.

Název v anglickém jazyce

Acoustical Enrichment during Early Development Improves Response Reliability in the Adult Auditory Cortex of the Rat

Popis výsledku anglicky

It is well known that auditory experience during early development shapes response properties of auditory cortex (AC) neurons, influencing, for example, tonotopical arrangement, response thresholds and strength, or frequency selectivity. Here, we show that rearing rat pups in a complex acoustically enriched environment leads to an increased reliability of responses of AC neurons, affecting both the rate and the temporal codes. For a repetitive stimulus, the neurons exhibit a lower spike count variance, indicating a more stable rate coding. At the level of individual spikes, the discharge patterns of individual neurons show a higher degree of similarity across stimulus repetitions. Furthermore, the neurons follow more precisely the temporal course of the stimulus, as manifested by improved phase-locking to temporally modulated sounds. The changes are persistent and present up to adulthood. The results document that besides basic alterations of receptive fields presented in our previous study, the acoustic environment during the critical period of postnatal development also leads to a decreased stochasticity and a higher reproducibility of neuronal spiking patterns.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

GBP304/12/G069: Projekt excelence v oblasti neurověd

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neural Plasticity

ISSN

2090-5904

e-ISSN

—

Svazek periodika

2018

Číslo periodika v rámci svazku

2018

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000434859600001

EID výsledku v databázi Scopus

2-s2.0-85054964872