Age-Related Differences in Hearing Function and Cochlear Morphology between Male and Female Fischer 344 Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00493493" target="_blank" >RIV/68378041:_____/18:00493493 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3389/fnagi.2017.00428" target="_blank" >http://dx.doi.org/10.3389/fnagi.2017.00428</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnagi.2017.00428" target="_blank" >10.3389/fnagi.2017.00428</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Age-Related Differences in Hearing Function and Cochlear Morphology between Male and Female Fischer 344 Rats

Popis výsledku v původním jazyce

Fischer 344 /F344/ rats represent a strain that is frequently used as a model for fast aging. In this study, we systematically compare the hearing function during aging in male and female F344 rats, by recording auditory brainstem responses /ABRs/ and distortion product otoacoustic emissions /DPOAEs/. In addition to this, the functional parameters are correlated with the cochlear histology. The parameters of the hearing function were not different in the young /3-month-old/ male and female F344 rats, the gender differences occurred only in adult and aged animals. In 8-24-month-old males, the ABR thresholds were higher and the ABR amplitudes were smaller than those measured in females of the same age. There were no gender differences in the neural adaptation tested by recording ABRs, elicited by a series of clicks with varying inter-click interval /ICI/. Amplitudes of DPOAEs in both the males and females decreased with age, but in the males, the decrease of DPOAE amplitudes was faster. In males older than 20 months, the DPOAEs were practically absent, whereas in 20-24-month-old females, the DPOAEs were still measurable. There were no gender differences in the number of surviving outer hair cells /OHC/ and the number of inner hair cell ribbon synapses in aged animals. The main difference was found in the stria vascularis /SV/. Whereas the SV was well preserved in females up to the age of 24 months, in most of the age-matched males the SV was evidently deteriorated. The results demonstrate more pronounced age-related changes in the cochlear morphology, hearing thresholds, ABR amplitudes and DPOAE amplitudes in F344 males compared with females.

Název v anglickém jazyce

Age-Related Differences in Hearing Function and Cochlear Morphology between Male and Female Fischer 344 Rats

Popis výsledku anglicky

Fischer 344 /F344/ rats represent a strain that is frequently used as a model for fast aging. In this study, we systematically compare the hearing function during aging in male and female F344 rats, by recording auditory brainstem responses /ABRs/ and distortion product otoacoustic emissions /DPOAEs/. In addition to this, the functional parameters are correlated with the cochlear histology. The parameters of the hearing function were not different in the young /3-month-old/ male and female F344 rats, the gender differences occurred only in adult and aged animals. In 8-24-month-old males, the ABR thresholds were higher and the ABR amplitudes were smaller than those measured in females of the same age. There were no gender differences in the neural adaptation tested by recording ABRs, elicited by a series of clicks with varying inter-click interval /ICI/. Amplitudes of DPOAEs in both the males and females decreased with age, but in the males, the decrease of DPOAE amplitudes was faster. In males older than 20 months, the DPOAEs were practically absent, whereas in 20-24-month-old females, the DPOAEs were still measurable. There were no gender differences in the number of surviving outer hair cells /OHC/ and the number of inner hair cell ribbon synapses in aged animals. The main difference was found in the stria vascularis /SV/. Whereas the SV was well preserved in females up to the age of 24 months, in most of the age-matched males the SV was evidently deteriorated. The results demonstrate more pronounced age-related changes in the cochlear morphology, hearing thresholds, ABR amplitudes and DPOAE amplitudes in F344 males compared with females.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Aging Neuroscience

ISSN

1663-4365

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

jan 4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

000419356200001

EID výsledku v databázi Scopus

2-s2.0-85040513534