A Short Overview of the Methods Frequently Used in Nanotoxicology

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00499208" target="_blank" >RIV/68378041:_____/18:00499208 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A Short Overview of the Methods Frequently Used in Nanotoxicology

Popis výsledku v původním jazyce

The particles of nanoscale are widespread. Manufactured nanoparticles can be found in food, cosmetics, clothes, medications, as well as secondary in the environment (air, water, soil). They are widely used in many areas because of their specific properties which may differ from those exhibited by their bulk forms. While these properties are unique, they may also cause unexpected effects on organisms and the environment. Therefore in compliance with the application of precautionary principle every engineered nanoparticle should undergo the safety assessment: 1) comprehensive physico-chemical characterisation, 2) evaluation of toxic effects by biological methods. Screening of toxic effects of nanomaterials, both engineered and environmental (originating from both human activity such as wood and coal combustion, industrial production, engine emissions etc., and natural processes such as volcanic activity) on human health includes the characterization of nanoparticles, analysis of cytotoxicity, genotoxicity or oxidative stress primarily using models of human cell lines. Methods investigating the impact of environmental or engineered NPs on the environment are not included in this short overview.

Název v anglickém jazyce

A Short Overview of the Methods Frequently Used in Nanotoxicology

Popis výsledku anglicky

The particles of nanoscale are widespread. Manufactured nanoparticles can be found in food, cosmetics, clothes, medications, as well as secondary in the environment (air, water, soil). They are widely used in many areas because of their specific properties which may differ from those exhibited by their bulk forms. While these properties are unique, they may also cause unexpected effects on organisms and the environment. Therefore in compliance with the application of precautionary principle every engineered nanoparticle should undergo the safety assessment: 1) comprehensive physico-chemical characterisation, 2) evaluation of toxic effects by biological methods. Screening of toxic effects of nanomaterials, both engineered and environmental (originating from both human activity such as wood and coal combustion, industrial production, engine emissions etc., and natural processes such as volcanic activity) on human health includes the characterization of nanoparticles, analysis of cytotoxicity, genotoxicity or oxidative stress primarily using models of human cell lines. Methods investigating the impact of environmental or engineered NPs on the environment are not included in this short overview.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1508" target="_blank" >LO1508: Genomika a proteomika při studiu mechanismů biologických účinků vyráběných nanočástic</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanostructures in Biomedicine: Their Regenerative and toxic properties

ISBN

978-80-906655-7-6

Počet stran výsledku

8

Strana od-do

4-11

Počet stran knihy

198

Název nakladatele

Proxima Tisk, s.r.o.

Místo vydání

Praha 3

Kód UT WoS kapitoly

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