Utilization of Micronucleus Assay in Nanotoxicology Research-Current State of the Art

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00499218" target="_blank" >RIV/68378041:_____/18:00499218 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Utilization of Micronucleus Assay in Nanotoxicology Research-Current State of the Art

Popis výsledku v původním jazyce

Micronucleus assay, which has been used for almost sixty years, is one of the basic methodological approaches of genetic toxicology. This is also evident from more than 10,500 references found using the keyword “micronucleus” in PubMed database. These studies, both in vitro and in vivo, which are discussed in the context of deleteriousness for humans, concern the evaluation of cytotoxicity and genotoxicity of numerous chemicals and in the last decade also nanomaterials (NMs) and nanoparticles (NPs). The aim of this mini-review was to track down the story of the development, improvement and possibilities of the micronucleus assay and revise its significant achievements in the field of nanotoxicology research in both in vitro and in vivo studies.

Název v anglickém jazyce

Utilization of Micronucleus Assay in Nanotoxicology Research-Current State of the Art

Popis výsledku anglicky

Micronucleus assay, which has been used for almost sixty years, is one of the basic methodological approaches of genetic toxicology. This is also evident from more than 10,500 references found using the keyword “micronucleus” in PubMed database. These studies, both in vitro and in vivo, which are discussed in the context of deleteriousness for humans, concern the evaluation of cytotoxicity and genotoxicity of numerous chemicals and in the last decade also nanomaterials (NMs) and nanoparticles (NPs). The aim of this mini-review was to track down the story of the development, improvement and possibilities of the micronucleus assay and revise its significant achievements in the field of nanotoxicology research in both in vitro and in vivo studies.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1508" target="_blank" >LO1508: Genomika a proteomika při studiu mechanismů biologických účinků vyráběných nanočástic</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanostructures in Biomedicine: Their Regenerative and toxic properties

ISBN

978-80-906655-7-6

Počet stran výsledku

5

Strana od-do

16-20

Počet stran knihy

198

Název nakladatele

Proxima Tisk, s.r.o.

Místo vydání

Praha 3

Kód UT WoS kapitoly

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