Skin Tissue Engineering and bFGF for Fibroblast Stimulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00500140" target="_blank" >RIV/68378041:_____/18:00500140 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Skin Tissue Engineering and bFGF for Fibroblast Stimulation

Popis výsledku v původním jazyce

Skin is the largest organ of the body and serves as a barrier between the internal and external environment. Its integrity is crucial for thermoregulation, hydration retention and especially protection against infection. In order to facilitate its essential functions, the skin continuously undergoes renewal. Wound healing is a complex process which involves the coordinated action of many bioactive molecules and numerous cell types. Even though the regeneration capacity of the organism itself is wide, there are certain conditions which can prolong the healing or even make it impossible thus leading to a chronic wound, these can also increase health care costs. Tissue engineering brings new alternative strategies of wound healing and tissue regeneration. A noncellular scaffold made of biocompatible material enriched with a stimulating growth factor, could support and accelerate damaged tissue restoration. This would be beneficial for patients with critical size skin defects such as diabetic ulcers or with deep burns. This chapter reviews the basic principles of skin tissue engineering. It will be focused on skin anatomy, skin substitutes and the basic fibroblast growth factor function.

Název v anglickém jazyce

Skin Tissue Engineering and bFGF for Fibroblast Stimulation

Popis výsledku anglicky

Skin is the largest organ of the body and serves as a barrier between the internal and external environment. Its integrity is crucial for thermoregulation, hydration retention and especially protection against infection. In order to facilitate its essential functions, the skin continuously undergoes renewal. Wound healing is a complex process which involves the coordinated action of many bioactive molecules and numerous cell types. Even though the regeneration capacity of the organism itself is wide, there are certain conditions which can prolong the healing or even make it impossible thus leading to a chronic wound, these can also increase health care costs. Tissue engineering brings new alternative strategies of wound healing and tissue regeneration. A noncellular scaffold made of biocompatible material enriched with a stimulating growth factor, could support and accelerate damaged tissue restoration. This would be beneficial for patients with critical size skin defects such as diabetic ulcers or with deep burns. This chapter reviews the basic principles of skin tissue engineering. It will be focused on skin anatomy, skin substitutes and the basic fibroblast growth factor function.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1508" target="_blank" >LO1508: Genomika a proteomika při studiu mechanismů biologických účinků vyráběných nanočástic</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanostructures in Biomedicine: Their Regenerative and toxic properties

ISBN

978-80-906655-7-6

Počet stran výsledku

4

Strana od-do

161-164

Počet stran knihy

198

Název nakladatele

Proxima Tisk, s.r.o.

Místo vydání

Praha 3

Kód UT WoS kapitoly

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