Gene Therapy and Drug Delivery: the Future of Cancer Treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00500145" target="_blank" >RIV/68378041:_____/18:00500145 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Gene Therapy and Drug Delivery: the Future of Cancer Treatment

Popis výsledku v původním jazyce

The microRNA(miRNA)-34a is an important regulator of tumor suppression: it controls the expression of several target proteins involved in the cell cycle, differentiation and apoptosis, and antagonizes the processes that are necessary for basic cancer cell viability as well as cancer stemness, metastasis, and chemoresistance. nGiven the anti-oncogenic activity of miR-34a, the substantial benefits of a new therapeutic concept based on nanotechnology delivery of miRNA were proved in this study using biocompatible fluorescent nanodiamond particles in order to treat prostate cancer.nOur findings suggest that the replacement of oncosuppressor miRNA-34a provides an effective strategy for cancer therapy and the nanodiamonds-based delivery system seems to be an excellent system for safe and effective targeting of the tumor.n

Název v anglickém jazyce

Gene Therapy and Drug Delivery: the Future of Cancer Treatment

Popis výsledku anglicky

The microRNA(miRNA)-34a is an important regulator of tumor suppression: it controls the expression of several target proteins involved in the cell cycle, differentiation and apoptosis, and antagonizes the processes that are necessary for basic cancer cell viability as well as cancer stemness, metastasis, and chemoresistance. nGiven the anti-oncogenic activity of miR-34a, the substantial benefits of a new therapeutic concept based on nanotechnology delivery of miRNA were proved in this study using biocompatible fluorescent nanodiamond particles in order to treat prostate cancer.nOur findings suggest that the replacement of oncosuppressor miRNA-34a provides an effective strategy for cancer therapy and the nanodiamonds-based delivery system seems to be an excellent system for safe and effective targeting of the tumor.n

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/LO1508" target="_blank" >LO1508: Genomika a proteomika při studiu mechanismů biologických účinků vyráběných nanočástic</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanostructures in Biomedicine: Their Regenerative and toxic properties

ISBN

978-80-906655-7-6

Počet stran výsledku

5

Strana od-do

178-182

Počet stran knihy

198

Název nakladatele

Proxima Tisk, s.r.o.

Místo vydání

Praha 3

Kód UT WoS kapitoly

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